119065-82-6Relevant articles and documents
Chemo-enzymatic total synthesis of 3-epiaustraline, australine, and 7-epialexine
Romero,Wong
, p. 8264 - 8268 (2000)
Sequential enzymatic aldol reaction and bis-reductive amination leads to the total syntheses of tetrahydroxylated pyrrolizidine alkaloids, 3-epiaustaline (14), australine (1), and 7-epialexine (11). This approach allows for their rapid construction without the need for protecting group manipulation of the hydroxyl functionality. In addition, an improved procedure for the asymmetric epoxidation of divinyl carbinol (3) was described, and the product was used in a concise synthesis of the required triol 7 and ent-7.
Total synthesis of uniflorine A, casuarine, australine, 3-epi-australine, and 3,7-di-epi-australine from a common precursor
Ritthiwigrom, Thunwadee,Willis, Anthony C.,Pyne, Stephen G.
supporting information; experimental part, p. 815 - 824 (2010/06/15)
(Chemical Equation Presented) Aflexible method for the diastereoselective total synthesis of the pyrrolizidine alkaloids uniflorine A, casuarine, australine, and 3-epi-australine and the unnatural epimer 3,7-di-epi-australine from a common chiral 2,5-dihydropyrrole precursor is described. 2009 American Chemical Society.