1193-96-0Relevant articles and documents
Cupric Ion Catalyzed Ester Hydrolysis of O-Acetyl-2-pyridinecarboxaldoxime. Nucleophilic Attack by Metal-Bound Water
Suh, Junghun,Cheong, Minsek,Suh, Myunghyun Paik
, p. 1654 - 1657 (1982)
The ester hydrolysis of O-acetyl-2-pyridinecarboxaldoxime is catalyzed by Cu2+.Thus, apparent rates for the hydroxide path and the water path are enhanced by 2.2x107 and 1.1x104 times, respectively.Detailed analysis indicates that the Cu2+-bound hydroxide ion or water molecule reacts with the carbonyl caarbon of the complexed ester.Thus, the catalysis includes increases in the effective concentrations of the attacking nucleophiles as well as enhancement in the leaving group ability.Besides, furhter catalysis in the attack of the coordinated water by general bases is suggested.Implications of the present results on the breakdown of the acyl carboxypeptidase A intermediate are discussed.
The effect of neutral oximes on the reactivation of human acetylcholinesterase inhibited with paraoxon
Ribeiro, Tatiana S.,Prates, Arthur,Alves, Se?rgio R.,Oliveira-Silva, Jefferson J.,Riehl, Carlos A. S.,Figueroa-Villar, J. Daniel
, p. 1216 - 1225 (2012)
Important defense agents against chemical warfare weapons, which are reactivators of human acetylcholinesterase (huAChE) inhibited by neurotoxic organophosphorus compounds (OP), need a reasonable permeation of the hematoencephalic barrier (HB). In this wo
3-methyl-4-oxa-5-azahomoadamantane as an organocatalyst for the aerobic oxidation of primary amines to oximes in water
Yu, Jiatao,Jin, Yong,Lu, Ming
supporting information, p. 1175 - 1180 (2015/04/22)
A simple and efficient catalytic system for the aerobic oxidation of primary amines into corresponding oximes has been developed, with 3-methyl-4-oxa-5-azahomoadamantane as catalyst, acetaldoxime as co-catalyst and water as solvent. This process, which uses oxygen (O2) as an economic and green oxidant and water as a green solvent, tolerates a wide range of substrates, affording the target oximes in moderate to excellent yields. It was found that high selectivity was achieved when 3-methyl-4-oxa-5-azahomoadamantane was used, and E-type oximes were the only detected products. A possible mechanism for this catalytic process is proposed.
