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1194-76-9

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1194-76-9 Usage

Description

5-Chloro-6-hydroxy-2-MethylpyriMidin-4(3H)-one, also known as N-Methyl-5-chloro-6-hydroxy-4(3H)-pyrimidinone, is a pyrimidine derivative with potential applications in pharmaceutical research. It is recognized for its ability to inhibit viral and fungal enzymes, making it a valuable starting material for the synthesis of antiviral and antifungal agents. Its unique structure and properties position it as a promising candidate for further research and therapeutic development in the field of medicinal chemistry.

Uses

Used in Pharmaceutical Research:
5-Chloro-6-hydroxy-2-MethylpyriMidin-4(3H)-one is used as a starting material for the synthesis of antiviral and antifungal agents due to its ability to inhibit the enzymes of these pathogens.
Used in Antiviral Drug Development:
In the Antiviral Industry, 5-Chloro-6-hydroxy-2-MethylpyriMidin-4(3H)-one is used as a key component in the development of new antiviral drugs, leveraging its enzyme-inhibiting properties to combat viral infections.
Used in Antifungal Drug Development:
Similarly, in the Antifungal Industry, this compound is utilized for the development of new antifungal medications, capitalizing on its capacity to inhibit fungal enzymes and thus treat fungal infections.
Used in Medicinal Chemistry:
5-Chloro-6-hydroxy-2-MethylpyriMidin-4(3H)-one is also used in medicinal chemistry as a promising candidate for the exploration of its potential therapeutic applications beyond its known antifungal and antibacterial properties, given its unique chemical structure and activity.

Check Digit Verification of cas no

The CAS Registry Mumber 1194-76-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,9 and 4 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1194-76:
(6*1)+(5*1)+(4*9)+(3*4)+(2*7)+(1*6)=79
79 % 10 = 9
So 1194-76-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H5ClN2O2/c1-2-7-4(9)3(6)5(10)8-2/h1H3,(H2,7,8,9,10)

1194-76-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Chloro-6-hydroxy-2-methylpyrimidin-4(3H)-one

1.2 Other means of identification

Product number -
Other names 5-chloro-4-hydroxy-2-methyl-1H-pyrimidin-6-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1194-76-9 SDS

1194-76-9Downstream Products

1194-76-9Relevant articles and documents

Ylides of Heterocycles. VII. . I-, N-, P- and S-Ylides of Pyrimidones

Habib, Nargues Samuel,Kappe, Thomas

, p. 385 - 388 (2007/10/02)

The reaction of pyrimidone derivatives 1a-d with iodosobenzene prepared in situ from diacetoxyiodobenzene or dichloroiodobenzene afforded the iodonium-ylides 2a-d in good yields.Their thermal rearrangement produced 5-iodo-4-phenoxy-pyrimidin-6(1H)-ones 3a-c.Reductive deiodination of 3 gave the corresponding 4-phenoxypyrimidin-6(1H)-ones 4a-c.Acid catalized treatment of the iodonium-ylides 2a-d with nucleophiles such as pyridine, nicotinamide, isoquinoline, or triphenylphosphine produced the corresponding N- or P-ylides 7, 8, 9, and 10, respectively.The thiophanium-ylides 11a,c were obtained from the iodonium-ylides 2 without the use of a catalyst.The pyridinium-ylides 7 have also been prepared from the 5-halopyrimidones 5 or 6 which in turn could be obtained from the reactive iodonium-ylides 2 with hydrochloric or hydrobromic acid, respectively.

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