120072-08-4

• 

• Basic information

  1. Product Name: N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide
  2. Synonyms: N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide;1-(2-(1H-pyrazol-1-yl)ethyl)-4-(4-methylthiazol-2-yl)-4-(N-phenylpropionamide)piperidine
  3. CAS NO:120072-08-4
  4. Molecular Formula: C₂₄H₂₈FN₃OS₂
  5. Molecular Weight: 457.63
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 120072-08-4.mol
  9. Article Data: 1

• Chemical Properties

  1. Melting Point: 202-204 °C
  2. Boiling Point: 590.8°Cat760mmHg
  3. Flash Point: 311.1°C
  4. Appearance: /
  5. Density: 1.254g/cm³
  6. Vapor Pressure: 6.19E-14mmHg at 25°C
  7. Refractive Index: 1.617
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. PKA: 7.41±0.20(Predicted)
  11. CAS DataBase Reference: N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide(CAS DataBase Reference)
  12. NIST Chemistry Reference: N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide(120072-08-4)
  13. EPA Substance Registry System: N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-yl ethyl)-4-piperidyl]propanamide(120072-08-4)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 120072-08-4(Hazardous Substances Data)

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• Usage
• SDS
• Upstream product
• Downstream Products
• Article

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120072-08-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 120072-08-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,0,7 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 120072-08:
(8*1)+(7*2)+(6*0)+(5*0)+(4*7)+(3*2)+(2*0)+(1*8)=64
64 % 10 = 4
So 120072-08-4 is a valid CAS Registry Number.

InChI:InChI=1/C24H28FN3OS2/c1-3-22(29)28(21-7-5-4-6-20(21)25)24(23-26-18(2)16-31-23)10-13-27(14-11-24)12-8-19-9-15-30-17-19/h4-7,9,15-17H,3,8,10-14H2,1-2H3

120072-08-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	N-(2-fluorophenyl)-N-[4-(4-methyl-1,3-thiazol-2-yl)-1-(2-thiophen-3-ylethyl)piperidin-4-yl]propanamide

1.2 Other means of identification

Product number	-
Other names	-

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120072-08-4 SDS

120072-08-4Upstream product

• 122823-36-3 N-(2-Fluoro-phenyl)-N-[4-(4-methyl-thiazol-2-yl)-piperidin-4-yl]-propionamide 
• 122823-28-3 N-[1-Benzyl-4-(4-methyl-thiazol-2-yl)-piperidin-4-yl]-N-(2-fluoro-phenyl)-propionamide 
• 120517-24-0 [1-Benzyl-4-(4-methyl-thiazol-2-yl)-piperidin-4-yl]-(2-fluoro-phenyl)-amine 
• 120070-56-6 1-benzyl-4-(2-fluorophenylamino)piperidine-4-carbonitrile 

120072-08-4Downstream Products

120072-08-4Relevant articles and documents

4-phenyl- and 4-heteroaryl-4-anilidopiperidines. A novel class of analgesic and anesthetic agents

Kudzma,Severnak,Benvenga,Ezell,Ossipov,Knight,Rudo,Spencer,Spaulding

, p. 2534 - 2542 (2007/10/02)

The incorporation of the 4-phenylpiperidine pharmacophore found in morphine into 4-anilidopiperidines related to fentanyl led to a novel class of potent opioid analgesic and anesthetic agents with a favorable pharmacological profile. The synthesis analgesic activity, and anesthetic properties of a series of 4-phenyl-4-anilidopiperidines (13-29) are discussed. Isosteric replacement of the phenyl by various heteroaryl substituents extended the series to include 4-heteroaryl-4-anilidopiperidines (30-53). Within this group, 1-[2-(1H-pyrazol-1-yl)ethyl]4-4(4-methylthiazol-2-yl)-4-(N- phenylpropionamido)piperidine (48), exhibited high analgesic potency, short duration of action, rapid recovery of motor coordination following anesthetic doses, and greater cardiovascular and respiratory safety during anesthesia as compared with opioids fentanyl (1) and alfentanil (2) currently in clinical use. Such analgesics could be of great utility to clinicians in the expanding outpatient surgical arena and for patient-controlled analgesia and computer assisted continuous infusion pain control techniques.

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