120615-22-7Relevant articles and documents
Synthesis, Structure, and Antiparasitic Activity of Sulfamoyl Derivatives of Ribavirin
Kini, Ganesh D.,Henry, Elizabeth M.,Robins, Roland K.,Larson, Steven B.,Marr, J. Joseph,et al.
, p. 44 - 48 (1990)
The triazole nucleoside derivatives 1-(5'-O-sulfamoyl-β-D-ribofuranosyl)triazole-3-carboxamide (2), 1-(5'-O-sufamoyl-β-D-ribofuranosyl)triazole-3-thiocarboxamide (3), and 1-(5'-O-sulfamoyl-β-D-ribofuranosyl)triazole-3-carbonitrile (4) were synthesized.Suitable protected triazole nucleosides were converted to their corresponding 5'-sulfamoyl derivatives, which on subsequent deprotection gave the desired compounds in good yields.The structures of compounds 2-4 were confirmed by X-ray crystallographic analysis.All three compounds showed significant activity in vitro, while 2 showed significant activity in vivo against Leishmania donovani and Trypanosoma brucei.