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121569-61-7

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121569-61-7 Usage

Description

UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01 first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC50 = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.

Uses

Different sources of media describe the Uses of 121569-61-7 differently. You can refer to the following data:
1. UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.
2. UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor.

references

[1] takahashi, i. ,saitoh, y.,yoshida, m., et al. ucn-01 and ucn-02, new selective inhibitors of protein kinase c. ii. purification, physico-chemical properties, structural determination and biological activities. j.antibiot.(tokyo) 42(4), 571-576 (1989).[2] newton a c. protein kinase c: structure, function, and regulation[j]. journal of biological chemistry, 1995, 270(48): 28495-28498.

Check Digit Verification of cas no

The CAS Registry Mumber 121569-61-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,5,6 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 121569-61:
(8*1)+(7*2)+(6*1)+(5*5)+(4*6)+(3*9)+(2*6)+(1*1)=117
117 % 10 = 7
So 121569-61-7 is a valid CAS Registry Number.
InChI:InChI=1/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27+,28+/m1/s1

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