121625-72-7Relevant articles and documents
1-Isobutyl-2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-3-indoleacetic acid
Deepthi,Pattabhi, Vasantha,Nagarajan
, p. 100 - 102 (1999)
The title compound (C17H25NO3) is a perhydro-indoleacetic acid which exhibits hypoglycemic activity. The cyclohexyl ring adopts a sofa conformation. The molecule contains an intramolecular O-H...O hydrogen bond.
Synthesis and oral hypoglycemic properties of two 4-oxo-4,5,6,7-tetrahydroindole-3-acetic acids
Nagarajan,Talwalker,Goud,Shah,Shenoy
, p. 548 - 550 (2007/10/02)
Condensation of β-acetyl-2-hydroxy-4,4-dimethyl-6-oxo-1- cyclohexene-1-propionic acid (3) with n-butyl and isobutylamines affords the title acids 4 and 5, respectively, which show good oral hypoglycemic activity in normal rats. Acids 4 and 5, are also active in streptozocin-induced diabetic rats. Results of extensive pharmacological and acute toxicity tests are reported.