121910-87-0Relevant articles and documents
A versatile catalyst system for enantioselective synthesis of 2-substituted 1,4-benzodioxanes
Chong, Eugene,Qu, Bo,Zhang, Yongda,Cannone, Zachary P.,Leung, Joyce C.,Tcyrulnikov, Sergei,Nguyen, Khoa D.,Haddad, Nizar,Biswas, Soumik,Hou, Xiaowen,Kaczanowska, Katarzyna,Chwalba, Micha?,Tracz, Andrzej,Czarnocki, Stefan,Song, Jinhua J.,Kozlowski, Marisa C.,Senanayake, Chris H.
, p. 4339 - 4345 (2019)
We report the synthesis of enantiomerically enriched 1,4-benzodioxanes containing alkyl, aryl, heteroaryl, and/or carbonyl substituents at the 2-position. The starting 1,4-benzodioxines were readily synthesized via ring closing metathesis using an efficient nitro-Grela catalyst at ppm levels. Excellent enantioselectivities of up to 99:1 er were obtained by using the versatile catalyst system [Ir(cod)Cl]2/BIDIME-dimer in the asymmetric hydrogenation of 2-substituted 1,4-benzodioxines. Furthermore, DFT calculations reveal that the selectivity of the process is controlled by the protonation step; and coordinating groups on the substrate may alter the interaction with the catalyst, resulting in a change in the facial selectivity.
Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
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Page/Page column 31-32, (2008/06/13)
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ("ADHD"), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.
NIS or NBS mediated formation of halo acetals. A convenient method for the one pot disubstitution of 1,4-benzodioxin
Sergi Capilla,Hernandez, Nathalie,Pujol, Ma. Dolors
, p. 135 - 141 (2007/10/03)
2,3-Substituted-1,4-benzodioxins are easily obtained under mild conditions in one-pot reaction from 1,4-benzodioxin with electrophilic halogen as iodine (NIS) or bromine (NBS) and the appropriate alcohol or phenol, in dichloromethane.
