Welcome to LookChem.com Sign In|Join Free

CAS

  • or

122-70-3

Post Buying Request

122-70-3 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

122-70-3 Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 122-70-3 differently. You can refer to the following data:
1. Clear colorless liquid
2. Phenethyl propionate has a very sweet odor reminiscent of red rose with a fruity undertone. It has a honey-like, warm, sweet raspberry and strawberry-like flavor.

Occurrence

Reported found in peanut (Arachis hypogaea), guava fruit, guava peel, Camembert cheese, Gruyere de Comte cheese, other cheese, beer, rum, cider, roasted peanut and apple brandy.

Preparation

By esterification of phenyl alcohol with propionic acid.

General Description

Phenethyl propionate can be used as a flavoring agent and fragrance ingredient. It is reported to be found in commercial wines.

Safety Profile

Low toxicity by ingestion and skin contact. When heated to decomposition it emits acrid smoke and irritating fumes.

Check Digit Verification of cas no

The CAS Registry Mumber 122-70-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 122-70:
(5*1)+(4*2)+(3*2)+(2*7)+(1*0)=33
33 % 10 = 3
So 122-70-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3

122-70-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B21283)  2-Phenylethyl propionate, 97%   

  • 122-70-3

  • 50g

  • 391.0CNY

  • Detail
  • Alfa Aesar

  • (B21283)  2-Phenylethyl propionate, 97%   

  • 122-70-3

  • 250g

  • 1559.0CNY

  • Detail

122-70-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Phenylethyl Propionate

1.2 Other means of identification

Product number -
Other names Propanoic acid, 2-phenylethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:122-70-3 SDS

122-70-3Synthetic route

phenethyl 2-chloropropanoate

phenethyl 2-chloropropanoate

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; cesium acetate; isopropyl alcohol at 100℃; Schlenk technique; Inert atmosphere;67%
With [RhCl2(p-cymene)]2; cesium acetate In isopropyl alcohol at 20 - 100℃; for 20h; Inert atmosphere;67%
Multi-step reaction with 2 steps
1: sodium iodide / acetone / 50 °C
2: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; cesium acetate; isopropyl alcohol / 100 °C / Schlenk technique; Inert atmosphere
View Scheme
2-phenylethanol
60-12-8

2-phenylethanol

propionic acid
802294-64-0

propionic acid

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
With pyridine; N-Bromosuccinimide; triphenylphosphine In dichloromethane; pentane for 2h; Ambient temperature;93%
With ion-exchange resin KU-2-8 In benzene at 80 - 85℃;92%
With dmap; triphenylphosphine; iodosodilactone In chloroform for 2h; Reflux;92%
propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

2-phenylethanol
60-12-8

2-phenylethanol

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
With zirconocene bis(perfluorooctanesulfonate) trihydrate*(tetrahydrofuran) In neat (no solvent) at 65℃; for 6h; Sealed tube; Green chemistry; chemoselective reaction;90%
2-phenylethanol
60-12-8

2-phenylethanol

propionic acid anhydride
123-62-6

propionic acid anhydride

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
zinc(II) perchlorate at 20℃; for 1.25h;99%
With dmap for 0.05h; Irradiation; microwave;95%
propionic acid
802294-64-0

propionic acid

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
With tetradecyl(trihexyl)phosphonium bistriflamide; N-ethyl-N,N-diisopropylamine at 75℃;98%
With tetradecyl(trihexyl)phosphonium bistriflimide at 75℃; for 6h;98%
2-phenylethanol
60-12-8

2-phenylethanol

propionaldehyde
123-38-6

propionaldehyde

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; bromine; sodium hydrogencarbonate In dichloromethane; water89%
diethyl (1-oxopropyl)phosphonate
1523-68-8

diethyl (1-oxopropyl)phosphonate

2-phenylethanol
60-12-8

2-phenylethanol

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane for 0.166667h; Ambient temperature;70%
2-phenylethanol
60-12-8

2-phenylethanol

Ethyl propionate
105-37-3

Ethyl propionate

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
Stage #1: 2-phenylethanol With bis(cyclopentadienyl)titanium dichloride; manganese; diiodomethane In tetrahydrofuran at 20℃; for 2.5h; Inert atmosphere;
Stage #2: Ethyl propionate In tetrahydrofuran at 20℃; for 1.5h; Inert atmosphere;
With recombinant acyltransferase from Mycobacterium smegmatis In aq. phosphate buffer at 25℃; for 0.5h; pH=8; Concentration; Green chemistry; Enzymatic reaction;
phenethyl 2-iodopropanoate

phenethyl 2-iodopropanoate

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; cesium acetate; isopropyl alcohol at 100℃; Schlenk technique; Inert atmosphere;71%
2-phenylethanol
60-12-8

2-phenylethanol

ZnCl2

ZnCl2

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzene / 3 h / Ambient temperature
2: 2-propanol, di-tert-butyl hyponitrite / 5 h / 60 °C / average chain length radical chain
View Scheme
2-phenylethanol
60-12-8

2-phenylethanol

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 0 - 20 °C
2: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; cesium acetate; isopropyl alcohol / 100 °C / Schlenk technique; Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 0 - 20 °C
2: sodium iodide / acetone / 50 °C
3: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; cesium acetate; isopropyl alcohol / 100 °C / Schlenk technique; Inert atmosphere
View Scheme
2-bromophenylethyl alcohol
1074-16-4

2-bromophenylethyl alcohol

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; isopropyl alcohol; potassium tert-butylate / 100 °C / Schlenk technique; Inert atmosphere
2: pyridine / dichloromethane / 0 - 20 °C
3: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; cesium acetate; isopropyl alcohol / 100 °C / Schlenk technique; Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; isopropyl alcohol; potassium tert-butylate / 100 °C / Schlenk technique; Inert atmosphere
2: pyridine / dichloromethane / 0 - 20 °C
3: sodium iodide / acetone / 50 °C
4: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; cesium acetate; isopropyl alcohol / 100 °C / Schlenk technique; Inert atmosphere
View Scheme
benzene
71-43-2

benzene

aqueous KOH

aqueous KOH

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: anhydrous aluminum chloride / 4 h / 6 - 7 °C
1.2: 90 percent / water
2.1: 92 percent / ion-exchange resin KU-2-8 / benzene / 80 - 85 °C
View Scheme
2-Bromo-propionic acid phenethyl ester

2-Bromo-propionic acid phenethyl ester

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

Conditions
ConditionsYield
With 1,2,2,6,6-pentamethylpiperidine; trans-di-O-tert-butyl hyponitrite In acetonitrile at 60℃; for 5h;
With isopropyl alcohol; trans-di-O-tert-butyl hyponitrite at 60℃; for 5h; average chain length radical chain;
methanol
67-56-1

methanol

2-phenethyl propanoate
122-70-3

2-phenethyl propanoate

A

propanoic acid methyl ester
554-12-1

propanoic acid methyl ester

B

2-phenylethanol
60-12-8

2-phenylethanol

Conditions
ConditionsYield
[t-Bu2SnOH(Cl)]2 at 30℃; for 3.5h;A n/a
B 65 % Chromat.

122-70-3Relevant articles and documents

Efficient Enzymatic Preparation of Flavor Esters in Water

Perdomo, Igor Chiarelli,Gianolio, Stefania,Pinto, Andrea,Romano, Diego,Contente, Martina Letizia,Paradisi, Francesca,Molinari, Francesco

, p. 6517 - 6522 (2019/06/20)

A straightforward biocatalytic method for the enzymatic preparation of different flavor esters starting from primary alcohols (e.g., isoamyl, n-hexyl, geranyl, cinnamyl, 2-phenethyl, and benzyl alcohols) and naturally available ethyl esters (e.g., formate, acetate, propionate, and butyrate) was developed. The biotransformations are catalyzed by an acyltransferase from Mycobacterium smegmatis (MsAcT) and proceeded with excellent yields (80-97%) and short reaction times (30-120 min), even when high substrate concentrations (up to 0.5 M) were used. This enzymatic strategy represents an efficient alternative to the application of lipases in organic solvents and a significant improvement compared with already known methods in terms of reduced use of organic solvents, paving the way to sustainable and efficient preparation of natural flavoring agents.

Transfer Hydro-dehalogenation of Organic Halides Catalyzed by Ruthenium(II) Complex

You, Tingjie,Wang, Zhenrong,Chen, Jiajia,Xia, Yuanzhi

, p. 1340 - 1346 (2017/02/10)

A simple and efficient Ru(II)-catalyzed transfer hydro-dehalogenation of organic halides using 2-propanol solvent as the hydride source was reported. This methodology is applicable for hydro-dehalogenation of a variety of aromatic halides and α-haloesters and amides without additional ligand, and quantitative yields were achieved in many cases. The potential synthetic application of this method was demonstrated by efficient gram-scale transformation with catalyst loading as low as 0.5 mol %.

A microwave-assisted highly practical chemoselective esterification and amidation of carboxylic acids

Pathak, Gunindra,Das, Diparjun,Rokhum, Lalthazuala

, p. 93729 - 93740 (2016/10/21)

The ubiquitousness of esters and amide functionalities makes their coupling reaction one of the most sought-after organic transformations. Herein, we have described an efficient microwave-assisted synthesis of esters and amides. Soluble triphenylphosphine, in conjugation with molecular iodine, gave the desired products without the requirement for a base/catalyst. In addition, a solid-phase synthetic route is incorporated for the said conversion, which has added advantages over solution-phase pathways, such as low moisture sensitivity, easy handling, isolation of the product by simple filtration, and reusability. In short, our method is simple, mild, green, and highly chemoselective in nature.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 122-70-3