1223-36-5 Usage
Originator
Clofexamide ,CNRS
Manufacturing Process
In 1 L of water there is dissolved 116.0 g (1 mole) of N,Ndiethylethylenediamine and, under vigorous stirring at a temperature
maintained below 50°C, there is added 205.0 g (1 mole) of the chloride of pchlorphenoxyacetic acid. The solution becomes rapidly homogeneous; the
formation of the basic amide hydrochloride is rapidly completed by further
stirring the reaction mixture for 2 h at about 20°C. Then an excess of soda lye
is added and the basic amide formed is extracted by ether. The ethereal
solution is dried on anhydrous sodium sulfate and ether is distilled after that
the residue is dried. So 2-(p-chlorophenoxy)-N-(2-(diethylamino)ethyl)
acetamide is obtained.
Therapeutic Function
Antidepressant, Analgesic, Antiinflammatory, Local
anesthetic
Check Digit Verification of cas no
The CAS Registry Mumber 1223-36-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,2 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1223-36:
(6*1)+(5*2)+(4*2)+(3*3)+(2*3)+(1*6)=45
45 % 10 = 5
So 1223-36-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H21ClN2O2/c1-3-17(4-2)10-9-16-14(18)11-19-13-7-5-12(15)6-8-13/h5-8H,3-4,9-11H2,1-2H3,(H,16,18)
1223-36-5Relevant articles and documents
Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand
Liu, Feng,Wu, Na,Cheng, Xu
supporting information, p. 3015 - 3020 (2021/05/05)
Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.
