122795-13-5Relevant articles and documents
Elemental fluorine, Part 23: Direct fluorination of β-ketoesters as an approach to enantioselective fluorination
Chambers, Richard D.,Nakano, Takashi,Okazoe, Takashi,Sandford, Graham
, p. 792 - 798 (2009)
Attempts to develop a direct enantioselective fluorination protocol using elemental fluorine and an appropriate Lewis acid and chiral ligand system are described.
Direct fluorination of 1,3-dicarbonyl compounds
Chambers, Richard D.,Greenhall, Martin P.,Hutchinson, John
, p. 1 - 8 (1996)
In acid media, 1,3-diketones and 1,3-keloesters can be fluorinated in high yield and often with high conversion mainly to the corresponding 2-fluoro- compounds. Diesters such as diethyl malonate do not react with fluorine under the same reaction conditions. The mechanism of these reactions has been investigated and while the identity of the electrophilic fluorinating species is uncertain, we believe that the essential features of the reaction pathway are understood. Copyright
Chiral 1H NMR Analysis of Carbonyl Compounds Enabled by Cationic Cobalt Complex
Jang, Sumin,Kim, Hyunwoo
supporting information, (2020/06/04)
We report a newly prepared cationic cobalt(III) complex as a general and efficient chiral solvating agent that discriminates carbonyl compounds including esters, amides, ketones, and aldehydes. This cobalt(III) complex was further utilized to directly analyze both the conversion and the enantiomeric excess at once in the asymmetric fluorination.
Enantioselective fluorination of β-ketoesters using tartrate derived bidentate bioxazoline-Cu(II) complexes
Balaraman, Kaluvu,Vasanthan, Ravichandran,Kesavan, Venkitasamy
, p. 919 - 924 (2013/09/23)
Enantioselective fluorination of aliphatic cyclic and acyclic β-ketoesters was achieved in excellent yield (up to 98%) with moderate to good enantioselectivities (up to 86% ee) using tartrate derived bidentate bioxazoline-Cu(II) complexes. This is the fir
Enantioselective α-fluorination and chlorination of β-ketoesters by cobalt catalyst
Kawatsura, Motoi,Hayashi, Shunsuke,Komatsu, Yuji,Hayase, Shuichi,Itoh, Toshiyuki
experimental part, p. 466 - 467 (2010/08/20)
We demonstrated the cobalt-catalyzed asymmetric a-fluorination and a-chlorination of β-ketoesters. Both reactions were achieved using a catalytic amount of Co(acac)2 with (R, R)Jacobsen's salen ligand; α-fluorinated or a-chlorinated products were thus obt
