122977-44-0 Usage
General Description
(+)-MOD-DIOP, or (+)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane, is a chiral diphosphine ligand widely used in asymmetric catalysis. It consists of two diphenylphosphino groups attached to a central butane moiety with two hydroxyl groups and an isopropylidene bridge. (+)-MOD-DIOP is known for its ability to coordinate with transition metals and promote enantioselective reactions in various types of catalytic processes, such as hydrogenation, allylic substitution, and C-C bond formation. Due to its high enantioselectivity and versatility, (+)-MOD-DIOP has been extensively utilized in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals by organic chemists. Its unique structural features and excellent performance in asymmetric catalysis have made it a valuable tool in the field of synthetic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 122977-44-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,9,7 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 122977-44:
(8*1)+(7*2)+(6*2)+(5*9)+(4*7)+(3*7)+(2*4)+(1*4)=140
140 % 10 = 0
So 122977-44-0 is a valid CAS Registry Number.
122977-44-0Relevant articles and documents
Hydroformylation process
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Page/Page column 4-5, (2008/06/13)
A process for the production of 4-hydroxybutyraldehyde is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst system comprising a rhodium complex and a 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-di-n-alkylphenyl)phosphino]butane. The process gives high yield of 4-hydroxybutyraldehyde compared to 3-hydroxy-2-methylpropionaldehyde.
HIGHLY EFFICIENT ASYMMETRIC HYDROGENATION OF ITACONIC ACID DERIVATIVES CATALYZED BY A MODIFIED DIOP-RHODIUM COMPLEX
Morimoto, Toshiaki,Chiba, Mitsuo,Achiwa, Kazuo
, p. 735 - 738 (2007/10/02)
A modified DIOP analogue bearing 4-methoxy and 3,5-dimethyl groups on each phenyl group has been synthesized.The rhodium complex of the ligand has been found to give very high optical yields in the asymmetric hydrogenation of itaconic acid and its derivatives bearing β-aryl groups, the products of which are key-intermediates for optically active lignan derivatives.
