123184-19-0 Usage
Description
2-BROMO-1-(2,6-DIMETHOXYPHENYL)ETHANONE is a chemical compound characterized by the molecular formula C11H13BrO3. It is a brominated ketone featuring a phenyl group that is substituted with two methoxy groups. 2-BROMO-1-(2,6-DIMETHOXYPHENYL)ETHANONE is recognized for its versatility in organic synthesis and chemical research, serving as a fundamental building block for the creation of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique properties and reactivity contribute to its utility in a range of chemical reactions, including Friedel-Crafts acylation, nucleophilic addition, and cross-coupling reactions. Furthermore, it holds promise for the development of new materials and as a precursor in the production of flavor and fragrance compounds, establishing its significance as a chemical reagent in the realm of organic chemistry.
Uses
Used in Pharmaceutical Industry:
2-BROMO-1-(2,6-DIMETHOXYPHENYL)ETHANONE is utilized as a key intermediate in the synthesis of various pharmaceuticals due to its ability to participate in multiple types of chemical reactions, facilitating the creation of diverse medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-1-(2,6-DIMETHOXYPHENYL)ETHANONE is employed as a building block for the development of agrochemicals, leveraging its reactivity to form new compounds with potential applications in crop protection and enhancement.
Used in Organic Synthesis:
2-BROMO-1-(2,6-DIMETHOXYPHENYL)ETHANONE is used as a versatile reagent in organic synthesis for its capacity to engage in Friedel-Crafts acylation, nucleophilic addition, and cross-coupling reactions, enabling the formation of a wide array of organic compounds.
Used in Material Science:
2-BROMO-1-(2,6-DIMETHOXYPHENYL)ETHANONE is also used as a precursor in material science for the development of new materials, capitalizing on its structural attributes to contribute to the properties of advanced materials.
Used in Flavor and Fragrance Industry:
2-BROMO-1-(2,6-DIMETHOXYPHENYL)ETHANONE is utilized as a precursor in the production of flavor and fragrance compounds, highlighting its potential to contribute to the creation of novel scents and tastes in various consumer products.
Check Digit Verification of cas no
The CAS Registry Mumber 123184-19-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,1,8 and 4 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 123184-19:
(8*1)+(7*2)+(6*3)+(5*1)+(4*8)+(3*4)+(2*1)+(1*9)=100
100 % 10 = 0
So 123184-19-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H11BrO3/c1-13-8-4-3-5-9(14-2)10(8)7(12)6-11/h3-5H,6H2,1-2H3
123184-19-0Relevant articles and documents
Microwave-assisted synthesis and luminescent activity of imidazo[1,2-a]pyridine derivatives
Rodríguez, Juan C.,Maldonado, Rony A.,Ramírez-García, Gonzalo,Díaz Cervantes, Erik,de la Cruz, Fabiola N.
, p. 2279 - 2287 (2020/03/16)
In this work, a series of phenacyl bromide derivatives was synthesized and employed as key intermediate for the synthesis of substituted imidazo[1,2-a]pyridines. First, phenacyl bromide molecules were obtained from the bromination reaction of acetophenones assisted by microwave irradiation, obtaining the products 4a-v in a 15 minutes reaction with yields in the range of 50% to 99%. Subsequently, the conjugation of these molecules with 2-aminopyridine conduced to the production of imidazo[1,2-a]pyridine derivatives (7a-v) in a 60-second reaction with yields of 24% to 99%. Improved yields were determined with respect to those obtained with more tedious methodologies like thermally and mechanically assisted routes. Intense luminescence emissions in the purple and blue regions of the electromagnetic spectra were observed under UV excitation according to the nature of the substituents. This environmentally friendly methodology is expected to constitute an important class of organic compounds for the development of biomarkers, photochemical sensors, and medicinal applications.
Identification of a potent new chemotype for the selective inhibition of PDE4
Skoumbourdis, Amanda P.,Huang, Ruili,Southall, Noel,Leister, William,Guo, Vicky,Cho, Ming-Hsuang,Inglese, James,Nirenberg, Marshall,Austin, Christopher P.,Xia, Menghang,Thomas, Craig J.
, p. 1297 - 1303 (2008/09/20)
A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure-activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented.
A new approach to the synthesis of 2-aminoimidazo[1,2-a]pyridine derivatives through rapid parallel synthesis
Jaramillo, Carlos,De Diego, J. Eugenio,Hamdouchi, Chafiq
, p. 1544 - 1546 (2007/10/03)
Different substituted 6-(2,6-difluorobenzoyl)-imidazopyridines 3 have been prepared using rapid parallel synthesis. Key cyanamide intermediate 4 was prepared from chloropyridine 1, and alkylated at the endocyclic nitrogen with different bromoacetophenones (prepared also in rapid parallel synthesis fashion). Subsequent cyclization was performed in situ with EtOAc/H2O to give target molecules.
