123994-81-0 Usage
General Description
2-[(3,4-dichlorophenyl)amino]-3,7-dihydro-6H-purin-6-one, also known as Zebularine, is a chemical compound that belongs to the class of purine analogs. It is a synthetic nucleoside with potential antineoplastic and antiviral activities. Zebularine has been studied for its ability to inhibit DNA methylation, which can lead to the re-expression of silenced tumor suppressor genes and the inhibition of cancer cell growth. It has also shown promising results in the treatment of solid tumors and hematological malignancies. Additionally, zebularine has exhibited antiviral properties, making it a potential candidate for the development of antiviral drugs. Overall, the compound has potential therapeutic applications in cancer treatment and antiviral therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 123994-81-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,9 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 123994-81:
(8*1)+(7*2)+(6*3)+(5*9)+(4*9)+(3*4)+(2*8)+(1*1)=150
150 % 10 = 0
So 123994-81-0 is a valid CAS Registry Number.
123994-81-0Relevant articles and documents
Haloanilino derivatives of pyrimidines, purines, and purine nucleoside analogs: Synthesis and activity against human cytomegalovirus
Medveczky,Yang,Gambino,Medveczky,Wright
, p. 1811 - 1819 (2007/10/02)
2-Anilinopurines and 6-anilinopyrimidines bearing 3,4- or 3,5-dichloro substituents in the anilino ring inhibited virus-specific DNA synthesis by human cytomegalovirus (HCMV)-infected human embryonic lung (HEL) cells in culture. In general, active compounds had moderate to low selectivity for viral vs host cell DNA synthesis. Nucleoside and acyclonucleoside analogs of 2-(3,5-dichloroanilino)purines inhibited both HCMV and cellular DNA synthesis at similar concentrations. 2-Amino-4-chloro-6-(3,5- dichloroanilino)pyrimidine and several related compounds inhibited HCMV growth in yield reduction assays at concentrations that were nontoxic to HEL cells.