124076-65-9 Usage
Chemical class
Amidines
Target enzymes
Factor VIIa and factor Xa
Involvement in coagulation pathway
Potent inhibitor
Potential use
Anticoagulant and antithrombotic agent
Preclinical studies
Shown promising results in preventing blood clot formation
Therapeutic applications
Treatment and prevention of cardiovascular diseases and thrombotic disorders
Further research needed
Pharmacokinetic and pharmacodynamic properties evaluation
Safety and efficacy
To be ensured for clinical use
Check Digit Verification of cas no
The CAS Registry Mumber 124076-65-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,0,7 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 124076-65:
(8*1)+(7*2)+(6*4)+(5*0)+(4*7)+(3*6)+(2*6)+(1*5)=109
109 % 10 = 9
So 124076-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C19H24N4O4/c1-24-16-10-12(18(20)21)4-6-14(16)26-8-3-9-27-15-7-5-13(19(22)23)11-17(15)25-2/h4-7,10-11H,3,8-9H2,1-2H3,(H3,20,21)(H3,22,23)
124076-65-9Relevant articles and documents
Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia
Tidwell,Jones,Geratz,Ohemeng,Cory,Hall
, p. 1252 - 1257 (2007/10/02)
A series of 33 analogues of the anti-Pneumocystis carinii drug 1,5-bis(4-amidinophenoxy)pentane (pentamidine) was synthesized for screening against a rat model of P. carinii pneumonia (PCP). Twenty-five of the compounds showed efficacy against PCP when compared to a saline-treated control group. Two compounds, 1,4-bis(4-amidinophenoxy)butane (butamidine, 6) and 1,3-bis(4-amidino-2-methoxyphenoxy)propane (DAMP, 16), were statistically more effective than the parent drug in treating PCP in the rat model of infection. In addition to their activity against PCP, the compounds were also evaluated for antitrypsin activity, ability to inhibit thymidylate synthetase, affinity for DNA, and toxicity. No correlation was observed between the tested molecular interactions of the diamidines and their effectiveness against PCP.
