124959-55-3Relevant articles and documents
Synthesis of 4,6-disubstituted 2-(4-morpholinyl)pyrimidines by cross-coupling reactions using triorganoindium compounds
Martinez, M. Montserrat,Perez-Caaveiro, Cristina,Pena-Lopez, Miguel,Sarandeses, Luis A.,Perez Sestelo, Jose
, p. 9045 - 9051,7 (2012/12/12)
4,6-Disubstituted-2-(4-morpholinyl)pyrimidines, an important class of bioactive compounds, have been synthesized from 4,6-dichloro-2-(4-morpholinyl) pyrimidine by selective and sequential palladium-catalyzed cross-coupling reactions using triorganoindium reagents. This methodology, being efficient and versatile, allowed the synthesis of a variety of non-symmetrical pyrimidines functionalized at C-4 and C-6 positions.