126521-53-7Relevant articles and documents
Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity
Jia, Ruifang,Zhang, Jian,Bertagnin, Chiara,Cherukupalli, Srinivasulu,Ai, Wei,Ding, Xiao,Li, Zhuo,Zhang, Jiwei,Ju, Han,Ma, Xiuli,Loregian, Arianna,Huang, Bing,Zhan, Peng,Liu, Xinyong
, (2021/01/05)
Encouraged by our earlier discovery of N1-selective inhibitors, the 150-cavity of influenza virus neuraminidases (NAs) could be further exploited to yield more potent oseltamivir derivatives. Herein, we report the design, synthesis and biological evaluation of a series of novel oseltamivir derivatives via the structural modifications at C5–NH2 of oseltamivir targeting 150-cavity. Among them, compound 5c bearing 4-(3-methoxybenzyloxy)benzyl group exhibited the most potent activity, which was lower or modestly improved activities than oseltamivir carboxylate (OSC) against N1 (H1N1), N1 (H5N1) and N1 (H5N1–H274Y). Specifically, there was 30-fold loss of activity against the wild-type strain H1N1. However, 5c displayed 4.85-fold more potent activity than OSC against H5N1–H274Y NA. Also, 5c demonstrated low cytotoxicity in vitro and no acute toxicity in mice. Molecular docking studies provided insights into the high potency of 5c against N1 and N1–H274Y mutant NAs. Besides, the in silico prediction of physicochemical properties and CYP enzymatic inhibitory ability of representative compounds were conducted to evaluate their drug-like properties.
CYCLIC OLEFIN COMPOUND, PHOTOREACTIVE POLYMER AND ALIGNMENT LAYER COMPRISING THE SAME
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Paragraph 0169; 0170, (2016/12/12)
The present invention relates to: a cyclic olefin compound which exhibits excellent liquid crystal alignment properties and alignment speed, has a characteristic that the alignment direction can easily be varied depending on the polarization direction, an
3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization
Duplantier, Allen J.,Efremov, Ivan,Candler, John,Doran, Angela C.,Ganong, Alan H.,Haas, Jessica A.,Hanks, Ashley N.,Kraus, Kenneth G.,Lazzaro Jr., John T.,Lu, Jiemin,Maklad, Noha,McCarthy, Sheryl A.,O'Sullivan, Theresa J.,Rogers, Bruce N.,Siuciak, Judith A.,Spracklin, Douglas K.,Zhang, Lei
scheme or table, p. 2524 - 2529 (2010/03/03)
The discovery, synthesis and SAR of a novel series of 3-benzyl-1,3-oxazolidin-2-ones as positive allosteric modulators (PAMs) of mGluR2 is described. Expedient hit-to-lead work on a single HTS hit led to the identification of a ligand-efficient and struct
