126775-74-4Relevant articles and documents
Total synthesis of himastatin
Movassaghi, Mohammad,Pentelute, Bradley L.,Schissel, Carly K.,D’Angelo, Kyan A.
, p. 894 - 899 (2022/03/02)
The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach with a modular synthesis enabled expedient access to more than a dozen designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity.
Total synthesis of himastatin: Confirmation of the revised stereostructure
Kamenecka, Theodore M.,Danishefsky, Samuel J.
, p. 2995 - 2998 (2007/10/03)
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