127408-31-5

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• Basic information

  1. Product Name: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE
  2. Synonyms: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE;Y-26763
  3. CAS NO:127408-31-5
  4. Molecular Formula: C14H16N2O4
  5. Molecular Weight: 276.28784
  6. EINECS: N/A
  7. Product Categories: Potassium channel
  8. Mol File: 127408-31-5.mol
  9. Article Data: 0

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 455.4°Cat760mmHg
  3. Flash Point: 229.2°C
  4. Appearance: /
  5. Density: 1.36g/cm³
  6. Vapor Pressure: 4.4E-09mmHg at 25°C
  7. Refractive Index: 1.615
  8. Storage Temp.: Store at RT
  9. Solubility: N/A
  10. PKA: 8.69±0.60(Predicted)
  11. CAS DataBase Reference: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE(CAS DataBase Reference)
  12. NIST Chemistry Reference: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE(127408-31-5)
  13. EPA Substance Registry System: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE(127408-31-5)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 127408-31-5(Hazardous Substances Data)

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127408-31-5 Suppliers

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• Y-26763

  Cas No: 127408-31-5

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• Dayang Chem (Hangzhou) Co.,Ltd.
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• Y-26763

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• BOC Sciences
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• N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

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• ZHEJIANG JIUZHOU CHEM CO.,LTD
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• Y-26763

  Cas No: 127408-31-5

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• suzhou BetterBioChem Co., Ltd.
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• Y-26763;N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-diMethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetaMide

  Cas No: 127408-31-5

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• Wuxi Morality Chemical Co., Ltd
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• FT-0770570

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• Finetech Industry Limited
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• N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-hydroxyacetamide

  Cas No: 127408-31-5

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• NovaChemistry
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127408-31-5 Usage

Uses

Y-26763, is a Kir6 (KATP) channel opener. It also inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. In vivo, it has shown to have hypotension activity in rats and cardioprotective properties in dogs.

Biological Activity

K ATP channel opener and active metabolite of Y-27152 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide ). In vitro, causes relaxation of contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration.

Check Digit Verification of cas no

The CAS Registry Mumber 127408-31-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,4,0 and 8 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 127408-31:
(8*1)+(7*2)+(6*7)+(5*4)+(4*0)+(3*8)+(2*3)+(1*1)=115
115 % 10 = 5
So 127408-31-5 is a valid CAS Registry Number.

InChI:InChI=1/C14H16N2O4/c1-8(17)16(19)12-10-6-9(7-15)4-5-11(10)20-14(2,3)13(12)18/h4-6,12-13,18-19H,1-3H3/t12-,13+/m1/s1

127408-31-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name	N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-hydroxyacetamide

1.2 Other means of identification

Product number	-
Other names	HMS3268J05

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127408-31-5 SDS

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