127492-36-8 Usage
Description
(1E)-1,2-dideoxy-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-D-erythro-pent-1-enitol is a complex chemical compound that is a derivative of dioxo-dihydropyrimidin and D-erythro-pent-1-enitol. It has a unique chemical structure and properties that make it valuable for pharmaceutical research and potential therapeutic applications.
Uses
Used in Pharmaceutical Research:
(1E)-1,2-dideoxy-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-D-erythro-pent-1-enitol is used as a research compound for studying the interactions and effects of similar compounds in biological systems. Its precise chemical structure and properties make it a valuable tool for understanding the mechanisms of action and potential therapeutic benefits of related compounds.
Used in Medical Field:
(1E)-1,2-dideoxy-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-D-erythro-pent-1-enitol has potential therapeutic applications in the medical field. More research and study may reveal further uses and applications for this chemical in treating various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 127492-36-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,4,9 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 127492-36:
(8*1)+(7*2)+(6*7)+(5*4)+(4*9)+(3*2)+(2*3)+(1*6)=138
138 % 10 = 8
So 127492-36-8 is a valid CAS Registry Number.
127492-36-8Relevant articles and documents
Synthesis and Anti-HIV Evaluation of 2',3'-Dideoxyribo-5-chloropyrimidine Analogues: Reduced Toxicity of 5-Chlorinated 2',3'-Dideoxynucleosides
Aerschot, Arthur Van,Everaert, Dirk,Balzarini, Jan,Augustyns, Koen,Jie, Liu,at al.
, p. 1833 - 1839 (2007/10/02)
In view of the selective anti-HIV activity of 2',3'-dideoxy-3'-fluoro-5-chlorouridine (11), a series of eight 2',3'-dideoxy-5-chloropyrimidines were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus type 1 (HIV-1) replication in MT-4 cells.A marked improvement in selectivity was noted for the 5-chlorouracil derivatives of 2,3-dideoxyribofuranose, 3-azido-2,3-dideoxyribofuranose, and 3-fluoro-2,3-dideoxyribofuranose, mainly due to decreased toxicity of the compounds for the host cells.While chlorination of 2',3'-dideoxycytidine remo ved the anti-HIV activity, introduction of chlorine at the C-5 position of 3'-fluoro-, 3'-azido- or 2',3'-didehydro-2',3'-dideoxycytidine led to reduced cytotoxicity with only slightly reduced anti-HIV activity.X-ray analysis showed compound 11 to have two molecules in the asymmetric unit with κ = -168.8(3) deg and -131.3(3) deg and P = 179(1) deg and 163(1) deg, respectively; thus revealing no close resemblance to 3'-azido-3'-deoxythymidine (AZT).