129025-54-3 Usage
Description
2-(4-chlorophenyl)-3-ethyl-5-oxo-pyridazine-4-carboxylic acid, also known as clofencet-potassium, is a pyridazinone derivative characterized by the presence of a 4-chlorophenyl group, an ethyl group, and a carboxylic acid group at specific positions. It is primarily used as a chemical hybridization agent in the commercial production of hybrid seeds.
Uses
Used in Agriculture:
2-(4-chlorophenyl)-3-ethyl-5-oxo-pyridazine-4-carboxylic acid is used as a chemical hybridization agent for the production of hybrid seeds. It plays a crucial role in ensuring the genetic uniformity and stability of hybrid seeds, which is essential for consistent crop performance and yield.
It is important to note that the use of 2-(4-chlorophenyl)-3-ethyl-5-oxo-pyridazine-4-carboxylic acid, particularly as clofencet-potassium, is not approved within the European Union due to potential concerns regarding its safety and environmental impact.
Check Digit Verification of cas no
The CAS Registry Mumber 129025-54-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,0,2 and 5 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 129025-54:
(8*1)+(7*2)+(6*9)+(5*0)+(4*2)+(3*5)+(2*5)+(1*4)=113
113 % 10 = 3
So 129025-54-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H11ClN2O3/c1-2-10-12(13(18)19)11(17)7-15-16(10)9-5-3-8(14)4-6-9/h3-7H,2H2,1H3,(H,18,19)
129025-54-3Relevant articles and documents
Process research, development, and pilot-plant preparation of clofencet, a novel wheat hybridizing agent: Lewis acid-catalyzed reaction of ethyl diazoacetate with 4-chlorophenyl hydrazonoacetaldehyde
Clark, Jerry D.,Heise, Jerald D.,Shah, Ajit S.,Peterson, James C.,Chou, Shine K.,Levine, Jeffrey,Karakas, Achilles M.,Ma, Yinong,Ng, Kin-Yin,Patelis, Lefteris,Springer, John R.,Stano, Don R.,Wettach, Richard H.,Dutra, Gerard A.
, p. 176 - 185 (2013/09/04)
Described are studies directed toward the chemical research and development of an alternative synthesis to 9, the penultimate intermediate of clofencet (1), a novel wheat-hybridizing agent. Retrosynthetic analyses as well as the results obtained from feasibility studies are detailed, leading to the successful development of an alternative process. The key features of the novel route are a method for preparing on-scale ethyl diazoacetate (28) in a safe and effective manner, and the Lewis acid-catalyzed reaction of 28 with hydrazonoacetaldehyde 29, affording β-ketoester 30. The synthesis is completed via propionylation of 30, acid-catalyzed cyclization of 31 to pyridazinecarboxylic acid ester 32, followed by saponification and isolation of carboxylic acid 9. The results and challenges of eight pilot-plant runs are reported. The baseline process developed produced over 45 kg of 9 in 43-45% yield.
