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129098-58-4

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129098-58-4 Usage

General Description

"(R)-2-((4-CHLOROPHENOXY)METHYL)OXIRANE" is a chemical compound with the molecular formula C10H11ClO2. It is an epoxide, meaning it contains a three-membered ring consisting of one oxygen atom and two carbon atoms. The compound has a chlorine atom attached to a phenyl group, which is in turn connected to a methylene group that is part of the epoxide ring. (R)-2-((4-CHLOROPHENOXY)METHYL)OXIRANE may have applications in organic synthesis, as well as potentially being utilized as a starting material for the production of other chemical compounds. It is important to handle this compound with care, as epoxides can be hazardous if not handled properly.

Check Digit Verification of cas no

The CAS Registry Mumber 129098-58-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,0,9 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 129098-58:
(8*1)+(7*2)+(6*9)+(5*0)+(4*9)+(3*8)+(2*5)+(1*8)=154
154 % 10 = 4
So 129098-58-4 is a valid CAS Registry Number.

129098-58-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-2-[(4-chlorophenoxy)methyl]oxirane

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:129098-58-4 SDS

129098-58-4Relevant articles and documents

Chiral Bifunctional Metalloporphyrin Catalysts for Kinetic Resolution of Epoxides with Carbon Dioxide

Maeda, Chihiro,Mitsuzane, Mayato,Ema, Tadashi

supporting information, p. 1853 - 1856 (2019/03/11)

Chiral binaphthyl-strapped Zn(II) porphyrins with triazolium halide units were synthesized as bifunctional catalysts for kinetic resolution of epoxides with CO2. Several catalysts were screened by changing the linker length and nucleophilic counteranions, and the optimized catalyst accelerated the enantioselective reaction at ambient temperature to produce optically active cyclic carbonates and epoxides.

Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl) piperazine derivatives as T-type calcium channel blockers

Park, Jung-Eun,Ji, Wan Keun,Jang, Jae Wan,Pae, Ae Nim,Choi, Keehyun,Choi, Ki Hang,Kang, Jahyo,Roh, Eun Joo

supporting information, p. 1887 - 1890 (2013/04/10)

To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 2-hydroxy-3-phenoxypropyl piperazine derivatives were synthesized and evaluated for in vitro activities. Compound 6m and 6q showed high selectivity over hERG

Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antiseptics

Chavez, Sherry A.,Martinko, Alexander J.,Lau, Corinna,Pham, Michael N.,Cheng, Kui,Bevan, Douglas E.,Mollnes, Tom E.,Yin, Hang

, p. 4659 - 4669 (2011/09/15)

Toll-like receptor 4 (TLR4) induced proinflammatory signaling has been directly implicated in severe sepsis and represents an attractive therapeutic target. Herein, we report our investigations into the structure-activity relationship and preliminary drug metabolism/pharmacokinetics study of β-amino alcohol derivatives that inhibit the TLR4 signaling pathway. Lead compounds were identified from in vitro cellular examination with micromolar potency for their inhibitory effects on TLR4 signaling and subsequently assessed for their ability to suppress the TLR4-induced inflammatory response in an ex vivo whole blood model. In addition, the toxicology, specificity, solubility, brain-blood barrier permeability, and drug metabolism of several compounds were evaluated. Although further optimizations are needed, our findings lay the groundwork for the future drug development of this class of small molecule agents for the treatment of severe sepsis.

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