13040-58-9Relevant articles and documents
185. Ueber Pterinchemie. Zum Verlauf der katalytischen Reduktion von 6-Methylpterin
Ganguly, Abhoy N.,Sengupta, Pradip K.,Bieri, Jost H.,Visconti, Max
, p. 1754 - 1758 (1980)
The catalytic hydrogenation of 6-methylpterin (I) in neutral or weekly acidic solutions begins, as for the 7-methylpterin, by the thermodynamically controlled reduction of the 7,8-double bond.It is not possible to say, according to our experiments, which double bond, either the 5,6 or the 7,8, is first reduced in strongly acidic solution.However, a 5,8-reduction can be excluded.
HALOGENATION OF N-ACYL-α-AMINO KETONES
Zav'yalov, S. I.,Ezhova, G. I.
, p. 1830 - 1833 (1980)
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FORMATION OF SUBSTITUTED PTERIDINES FROM 5,6-DIAMINOPYRIMIDINES AND N-(ARYLSULFONYL)IMIDAZOLIN-2-ONES
Zav'yalov, S. I.,Zavozin, A. G.
, p. 1355 - 1357 (1981)
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Storm et al.
, p. 3925 (1971)
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Forrest,Walker
, p. 2077,2079 Anm.,2081 (1949)
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Zav'yalov et al.
, (1973)
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Ueber Pterinchemie. 73. Mitteilung. Zum Verlauf der katalytischen Reduktion von 7-Methylpterin
Ganguly, Abboy N.,Sengupta, Pradip K.,Bieri, Jost H.,Viscontini, Max
, p. 395 - 401 (1980)
The catalytic hydrogenation of 7-methylpterin (VII) in a neutral solution occurs first by the reduction of the 7,8-double bond (thermodynamically-controlled reaction) followed by the reduction of the 5,6-double bond.On the contrary, in an acidic medium like CF3COOH, the 5,6-double bond is reduced first (kinetically-controlled reaction).The dihydro-intermermediate then undergoes a -H-rearrangement leading to the formation of the thermodynamically more stable 7-methyl-7,8-dihydropterin (XV) which on further reduction gives 7-methyl-5,6,7,8-tetrahydropterin (VIII).The catalytic reduction of 7-methyl-7,8-dihydropterin (XV) with deuterium gives stereoselectively a sole product with D at C(6) in the equatorial position.
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Zav'yalov,Budkova
, (1978)
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