13140-89-1Relevant articles and documents
Broad Scope and High-Yield Access to Unsymmetrical Acyclic [11C]Ureas for Biomedical Imaging from [11C]Carbonyl Difluoride
Jakobsson, Jimmy E.,Jana, Susovan,Lu, Shuiyu,Pike, Victor W.,Telu, Sanjay
supporting information, p. 10369 - 10376 (2021/06/07)
Effective methods are needed for labelling acyclic ureas with carbon-11 (t1/2=20.4 min) as potential radiotracers for biomedical imaging with positron emission tomography (PET). Herein, we describe the rapid and high-yield syntheses of unsymmet
A New Convenient Method for the Synthesis of Symmetrical and Unsymmetrical N,N'-Disubstituted Ureas
Izdebski, Jan,Pawlak, Danuta
, p. 423 - 425 (2007/10/02)
A new method is described for the preparation of symmetrically and unsymmetrically disubstituted ureas by aminolysis of bis(4-nitrophenyl) carbonate.The second substitution is slower than the first one, and it is possible to isolate monosubstituted intermediates when equimolar amounts of substrates are used.The reaction of the intermediates with different amines give unsymmetrical derivatives of urea.