13182-82-6Relevant articles and documents
Imidazole derivatives as possible microbicides with dual protection
Kumar, Lalit,Sarswat, Amit,Lal, Nand,Sharma, Vishnu L.,Jain, Ashish,Kumar, Rajeev,Verma, Vikas,Maikhuri, Jagdamba P.,Kumar, Awanit,Shukla, Praveen K.,Gupta, Gopal
experimental part, p. 817 - 824 (2010/04/06)
Twenty seven derivatives (2-28) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol were synthesized and evaluated for anti-trichomonas, spermicidal and antifungal activities. Twenty six compounds were active against Trichomonas vaginalis at MIC ranging from 1-42 μM and seven compounds (9,18,19,22,24,26,28) immobilized 100% human spermatozoa at 1% concentration (w/v). Twenty three compounds (2,3,5,8-26,28) exhibited antifungal activity at 25-50 μg/mL concentration. Seven compounds (9,18,19,22,24,26,28) showed significant anti-trichomonas and spermicidal activities and also exhibited mild antifungal activity. All the compounds were highly safe towards human cervical cell line (HeLa) as shown by the cell-viability assay of HeLa cells at 200 μg/mL concentration, whereas nonoxynol-9 (N-9, the marketed spermicidal microbicide) was highly cytotoxic. Therefore, it may be concluded that introduction of the pharmacophore responsible for spermicidal activity into a proven anti-trichomonas structure may lead to a potent dual function microbicide better and safer than N-9.
Pharmaceutical compositions primarily for the treatment and prevention of genitourinary infections and their extragenital complications
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, (2008/06/13)
Compositions having synergistic effective amounts of one or more antibacterial agents, a nitroimidazole, and/or a sulfonamide or a molecule or compound having folic acid antagonist effect and nitroimidazole substitution in addition, with or without an ant
