132-20-7 Usage
Chemical Properties
white powder
Originator
Trimeton Maleate, Schering ,US,1948
Uses
Different sources of media describe the Uses of 132-20-7 differently. You can refer to the following data:
1. Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.
2. Antihistaminic;H1 antagonist
3. A H1 histamine receptor antagonist.
4. Used medicinally as an antihistaminic (merck).
Manufacturing Process
According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.
Therapeutic Function
Antihistaminic
General Description
Different sources of media describe the General Description of 132-20-7 differently. You can refer to the following data:
1. Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts.
2. White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.
Air & Water Reactions
Water soluble.
Reactivity Profile
Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
Fire Hazard
Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible.
Biochem/physiol Actions
Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 132-20-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 132-20:
(5*1)+(4*3)+(3*2)+(2*2)+(1*0)=27
27 % 10 = 7
So 132-20-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H20N2.C3H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;4-2(5)1-3(6)7/h3-10,12,15H,11,13H2,1-2H3;1H2,(H,4,5)(H,6,7)
132-20-7Relevant articles and documents
A synthetic method of pheniramine maleate
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, (2018/07/06)
A novel synthetic method of pheniramine maleate is provided. The method includes subjecting benzylboronic acid and 2-halogenpyridine to a condensation reaction to obtain 2-benzylpyridine, subjecting the 2-benzylpyridine and 2-dimethylaminoethyl halide hydrochloride to a substitution reaction to prepare pheniramine, and salifying the pheniramine with maleic acid to obtain the pheniramine maleate. The method is simple in process, high in yield, low in cost and easy in industrial production.