133001-05-5Relevant articles and documents
Method for synthesizing (Z)-3-halogenated-2-(4-fluorophenyl)-1-(2-chlorphenyl) propylene
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Paragraph 0020-0022; 0024-0029, (2021/04/17)
The invention discloses a method for synthesizing (Z)-3-halogenated-2-(4-fluorophenyl)-1- (2-chlorphenyl) propylene. The method comprises the following steps: mixing a raw material 1-halogenated-3-(2-chlorobenzene)-2- (4-fluorobenzene)-2-propanol with an organic solvent to obtain a material A, mixing an acid catalyst, acid anhydride and the organic solvent to obtain a material B, pumping the temperature-controlled material A and the temperature-controlled material B into a mixer by using a liquid conveying pump at the same time, and uniformly mixing the materials by using the mixer, feeding the mixture into a micro-channel reactor for reaction, stably maintaining the reaction at -20-60 DEG C for 15-550 seconds, collecting reaction liquid at the tail end of the reactor, and performing aftertreatment to obtain (Z)-3-halogenated-2- (4-fluorophenyl)-1-(2-chlorphenyl) propylene with the yield of 50-85 percent. The configuration selectivity of (Z)/(E) 3chloro2 (4fluorophenyl) 1 (2chlorphenyl) propylene in the method is as high as 11.4: 1, and the method has the advantages of high selectivity, simplicity and convenience in operation, good safety, high yield and the like, and is suitable for industrial production.