133860-42-1Relevant articles and documents
Synthesis and anthelmintic activity of 7-hydroxy-5-oxo-5H-thieno[3,2- b]pyran-6-carboxanilides and -6-thiocarboxanilides
Plant,Harder,Mencke,Bertram
, p. 351 - 358 (2007/10/03)
7-Hydroxy-5-oxo-5H-thieno[3,2-b]pyran-6-carboxanilides and -6- thiocarboxanilides represent a novel series of anthelmintic compounds, with broad-spectrum activity against important parasitic nematodes in sheep and dogs. In particular, an improved efficacy against Trichostrongylus colubriformis in sheep over the related 3-carbamoyl-4-hydroxycoumarins has been noted. New synthetic routes to the key intermediate, 7- hydroxythieno[3,2-b]pyran-5-one, have been developed.