133866-14-5Relevant articles and documents
ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS
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, (2011/02/18)
The disclosure relates to pharmacotherapy of a psychiatric disorder which is schizophrenia and/or anxiety, wherein schizophrenia includes schizophrenia related disorders such as brief psychotic disorders, delusional disorders, schizoaffective disorders, a
Alpha-aminoamide derivatives useful as analgesic agents
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, (2008/06/13)
The present invention relates to novel and known alpha-aminoamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic agents. In particular, the compounds of the present invention are endowed with analgesic properties and are particularly useful for the treatment and alleviation of chronic and neuropathic pain. Accordingly, one object of the present invention is to provide the use of a compound of formula (I) wherein: A is a —(CH2)m—, —(CH2)n—X— or —(CH2)v—O— group wherein m is an integer of 1 to 4, n is zero or an integer of 1 to 4, X is —S— or —NH—, and v is zero or an integer of 1 to 5; s is 1 or 2; R is a furyl, thienyl, or pyridyl ring or a phenyl ring optionally substituted by one or two substitutents independently chosen from halogen, cyano, C1-C4alkyl, C1-C4alkoxy and trifluoromethyl; R1is hydrogen or C1-C4alkyl; one of R2and R3is hydrogen and the other is hydrogen or C1-C4alkyl optionally substituted by hydroxy or phenyl; or R2and R3taken together with the carbon atom to which they are linked form a C3-C6cycloalkyl ring; or R2and R3are both methyl; R4is hydrogen or C1-C4alkyl.
