13534-98-0Relevant articles and documents
Preparation method of pyridine derivative (by machine translation)
-
Paragraph 0099-0102, (2019/12/02)
To the method, piperidine-4-one hydrochloride is used as a raw material, and a series of pyridine derivatives are obtained through halogenation reaction and elimination reaction. The reaction is eliminated by reacting piperidine-4-one hydrochloride with a specific amount of the 3,5 - halogenating agent in a halogenation 3, 3, 5 - reaction with a halogen-3, 3, 5, 5 - based reaction, followed by reaction with a pyridine derivative of a hydroxyl group, an amino group 4 - or a dimethylamino group, respectively, by eliminating the reaction with a different kind of basic agent. The method is simple and convenient to operate, mild in condition, short in technological process, low in waste water yield, environment-friendly, low in cost and beneficial to green industrial production of the pyridine derivative. (by machine translation)
Synthesis of pyrrolo[1,2-a]naphthyridines by Lewis acid mediated cycloisomerization
Flader, Anika,Parpart, Silvio,Ehlers, Peter,Langer, Peter
supporting information, p. 3216 - 3231 (2017/04/21)
Pyrrolo[1,2-a]naphthyridines were synthesized from 3-alkynyl-2-([1H]-pyrrol-1-yl)pyridines and 3-alkynyl-4-([1H]-pyrrol-1-yl)pyridines by cycloisomerization. The reactions are performed by application of the Lewis acids PtCl2 or Bi(OTf)3 without the need of further additives. With the described methods a number of derivatives containing a variety of functional groups have been synthesized in up to 78% yield.
Enantioselective halocyclization using reagents tailored for chiral anion phase-transfer catalysis
Wang, Yi-Ming,Wu, Jeffrey,Hoong, Christina,Rauniyar, Vivek,Toste, F. Dean
supporting information; experimental part, p. 12928 - 12931 (2012/10/08)
A chiral anion phase-transfer system for enantioselective halogenation is described. Highly insoluble, ionic reagents were developed as electrophilic bromine and iodine sources, and application of this system to o-anilidostyrenes afforded halogenated 4H-3,1-benzoxazines with excellent yield and enantioselectivity.
