135367-08-7Relevant articles and documents
Fluoralkenyl nortropanes
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Page column 16, (2008/06/13)
Provided are compounds of the following formula: wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.
Synthesis, in vitro characterization and ex vivo evaluation 2β-carbomethoxy-3β-(4-fluoroalkyl-3-halophenyl)nortropanes: New potential SERT imaging agents for PET or SPECT
Chen,Kilts,Camp,Ely,Malveaux,Votaw,Hoffman,Goodman
, p. S324-S326 (2007/10/03)
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Synthesis, ligand binding, QSAR, and CoMFA study of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters
Carroll,Gao,Rahman,Abraham,Parham,Lewin,Boja,Kuhar
, p. 2719 - 2725 (2007/10/02)
A series of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters (2) were synthesized and found to possess high affinity for the cocaine binding site in rat striatum. The p-chloro (2c) and p-iodo (2n) compounds, which were the most potent analogues prepared, were found to be 85 and 78 times more potent than (-)-cocaine. The p-bromo (2m) and p-methyl (2d) were also 56 and 60 times more potent than cocaine. QSAR and CoMFA studies were conducted to correlate binding affinity of the cocaine analogues with their structural features. Whereas the QSAR study gave relatively low correlations, the CoMFA study gave a correlation with high predictive value.