135886-70-3 Usage
Uses
Regulator (calcium).
Clinical Use
Gallium nitrate (Ganite) has been approved for the treatment of hypercalcemia of malignancy in patients
that do not respond to hydration. Its effectiveness stems from its ability to inhibit bone resorption despite the
presence of tumor-derived factors that promote calcium loss from the bone. Administered by infusion over 24
hours, the typical dose is 200 mg/m2
/day for five consecutive days. A lower dose is recommended if the
symptoms of hypercalcemia are mild (100 mg/m2
/day for 5 days). Steady state is achieved in 24 to 48 hours.
Maintenance of patient hydration is essential during treatment.
Metabolism
Gallium nitrate is not significantly metabolized
and is largely excreted through the kidneys. It is contraindicated in patients with severe renal impairment.
Renal function should be closely monitored in all patients receiving this agent.
Check Digit Verification of cas no
The CAS Registry Mumber 135886-70-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,8,8 and 6 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 135886-70:
(8*1)+(7*3)+(6*5)+(5*8)+(4*8)+(3*6)+(2*7)+(1*0)=163
163 % 10 = 3
So 135886-70-3 is a valid CAS Registry Number.
InChI:InChI=1/Ga.3HNO3.9H2O/c;3*2-1(3)4;;;;;;;;;/h;3*(H,2,3,4);9*1H2