136945-81-8Relevant articles and documents
Syntheses of (RS)- and (S)-(-)-nazlinin and (RS)- and (+)-6-azacyclodeca[5,4-b]indol-1-amine
Mahboobi,Wagner,Burgemeister
, p. 371 - 376 (1995)
(RS)-1-(4-Aminobutyl)-1,2,3,4-tetrahydro-β-carboline ((RS)-1) was synthesized in two different ways. The preparation of (S)-(-)-1 was performed both by asymmetric reduction with ≥ 95% ee and by synthesis from (S)-(+)-3. From this compound also (+)-6-azacy
Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology
Kabeshov, Mikhail A.,Musio, Biagia,Murray, Philip R.D.,Browne, Duncan L.,Ley, Steven V.
supporting information, p. 4618 - 4621 (2015/01/08)
An expedient synthesis of the indole alkaloid nazlinine is reported. Judicious choice of flow electrochemistry as an enabling technology has permitted the rapid generation of a small library of unnatural relatives of this biologically active molecule. Furthermore, by conducting the key electrochemical Shono oxidation in a flow cell, the loading of electrolyte can be significantly reduced to 20 mol % while maintaining a stable, broadly applicable process.