13698-49-2Relevant articles and documents
Urinary and biliary metabolites of 17α acetoxy 6 chloro 4,6 pregnadiene 3,20 dione in the rabbit
Abe,Kambegawa
, p. 2824 - 2829 (1974)
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Synthesis of 17α acetoxy 6 chloro 2α,3β dihydroxy 4,6 pregnadien 20 one, a metabolite of chlormadinone acetate
Abe,Kambegawa
, p. 1295 - 1299 (1973)
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Method for preparing delmadinone acetate product
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, (2019/03/06)
The invention provides a method for preparing a delmadinone acetate product. The method comprises the following steps: by taking IDD (1,4-Androstadienedione) as a raw material, firstly, enabling 17-site ketone in IDD molecules to react with acetone cyanohydrins in a first organic solvent under catalysis of an alkali, and introducing beta-hydroxyl and alpha-cyan into the 17-site so as to obtain hydroxyl cyanogens; preparing 1,6-bidehydrogenation-17a-hydroxyl progesterone from the hydroxyl cyanogens in the presence of methyl magnesium halide, a second organic solvent and an acid; further synthesizing a 6-site epoxy substance, further synthesizing 6-site chloride so as to obtain delmadinone, and finally carrying out 17-site esterification so as to obtain delmadinone acetate; and further carrying out heating backflow decoloring and recrystalization on the obtained delmadinone acetate with activated carbon in lower-carbon alcohol with the carbon number of smaller than 4, thereby obtaining the delmadinone acetate product. Compared with a conventional synthesis method, the method provided by the invention has multiple advantages of being simple and convenient in process operation, economic and environmental-friendly in production, high in total synthesis yield, high in product quality, low in production cost, and the like.
Antiandrogen. I. 2-Azapregnane and 2-oxapregnone steroids
Shibata,Takegawa,Koizumi,Yamakoshi,Shimazawa
, p. 935 - 941 (2007/10/02)
2-Azachlormadinone acetate (5a, 17-acetoxy-6-chloro-2-azapregna-4,6-diene-3,20-dione), 2-oxachlormadinone acetate (6, 17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) and the derivatives were prepared as potential antiandrogenic agents. Biological evaluation showed that 5a and 6 had a potent antiandrogenic activity when tested in the castrated male rat.
