13734-29-7 Usage
Description
BOC-LYS(TOS)-OH, also known as Nα-(tert-Butoxycarbonyl)-L-lysine (tosyl)amide, is an amino acid derivative that plays a crucial role in the field of peptide synthesis. It is a protected form of L-lysine, which is an essential amino acid for the human body. The BOC-LYS(TOS)-OH molecule features a tert-butoxycarbonyl (BOC) group for protection and a tosyl (TOS) group for activation, making it a versatile building block for the synthesis of various peptides and peptide-based compounds.
Uses
Used in Pharmaceutical Industry:
BOC-LYS(TOS)-OH is used as a key intermediate in the synthesis of various peptide-based drugs and therapeutic agents. Its application in this industry is primarily due to its ability to facilitate the formation of peptide bonds, which are the building blocks of proteins and peptides.
Used in Research and Development:
BOC-LYS(TOS)-OH is used as a reagent in the research and development of new peptide-based compounds. Its role in this application is to provide a protected and activated form of L-lysine, which can be easily incorporated into peptide sequences during synthesis.
Used in Peptide Synthesis:
BOC-LYS(TOS)-OH is used as a building block for the preparation of peptides, such as those with glycine or lysylglycine esters. Its application in this area is due to its ability to form stable peptide bonds with other amino acid residues, leading to the formation of desired peptide sequences.
Used in Synthesis of Vasopressin Hypotensive Agonist Peptides:
BOC-LYS(TOS)-OH has been specifically used in the synthesis of selective vasopressin hypotensive agonist peptides. These peptides have potential applications in the treatment of conditions related to blood pressure regulation, such as hypertension. The use of BOC-LYS(TOS)-OH in this context is attributed to its ability to facilitate the formation of the specific peptide sequences required for these agonist peptides.
Check Digit Verification of cas no
The CAS Registry Mumber 13734-29-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,3 and 4 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 13734-29:
(7*1)+(6*3)+(5*7)+(4*3)+(3*4)+(2*2)+(1*9)=97
97 % 10 = 7
So 13734-29-7 is a valid CAS Registry Number.
13734-29-7Relevant articles and documents
Selective Removal of Electron-Accepting p-Toluene- and Naphthalenesulfonyl Protecting Groups for Amino Function via Photoinduced Donor-Acceptor Ion Pairs with Electron-Donating Aromatics
Hamada, Tatsuo,Nishida, Atsushi,Yonemitsu, Osamu
, p. 140 - 145 (2007/10/02)
When N-tosylamines (3a, 3b, 7, 17a, 17b, 21, 23) in aqueous ethanol were irradiated with a high-pressure mercury lamp in the presence of an electron-donating aromatic such as 1,2- (6) and 1,4-dimethoxybenzenes (10) and 1,5-dimethoxynaphthalene (14) and a reductant (sodium borohydride, ascorbic acid, ammonia borane, hydrazine), a photochemical detosylation proceeded quite easily to give the corresponding amines (4a, 4b, 8, 18a, 18b, 22, 24) in the high yields.On irradiation in the presence of 10 and sodium borohydride, N-(naphthalenesulfonyl)phenethylamine (19) also gave 4a.Mechanistic studies based on fluorescence quenching, quantum yield measurement, and free energy change calculation show that this photoreaction involves an electron transfer from an electron-donating aromatic to an electron-accepting sulfonamide.A preliminary application for the synthesis of lysine peptides was also described.
