138154-38-8Relevant articles and documents
Novel inhibitors of NRH:Quinone oxidoreductase 2 (NQO2): Crystal structures, biochemical activity, and intracellular effects of imidazoacridin-6-ones
Dunstan, Mark S.,Barnes, John,Humphries, Matthew,Whitehead, Roger C.,Bryce, Richard A.,Leys, David,Stratford, Ian J.,Nolan, Karen A.
, p. 6597 - 6611 (2011/12/01)
Imidazoacridin-6-ones are shown to be potent nanomolar inhibitors of the enzyme NQO2. By use of computational molecular modeling, a reliable QSAR was established, relating inhibitory potency with calculated binding affinity. Further, crystal structures of