138330-18-4

• 

• Basic information

  1. Product Name: INCADRONATE
  2. Synonyms: ((cycloheptylamino)methylene)bis-phosphonicacidisodiumsalt;cimadronate;disodiumcycloheptylaminomethylenediphosphonate;incadronatesodium;ym175;INCADRONATE;Disodium cycloheptylaminomethylene bisphosphonate;DisodiuM CycloheptylaMinoMethylene diphosphate
  3. CAS NO:138330-18-4
  4. Molecular Formula: C8H17NNa2O6P2
  5. Molecular Weight: 331.15
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 138330-18-4.mol
  9. Article Data: 0

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 551.5 °C at 760 mmHg
  3. Flash Point: 287.4 °C
  4. Appearance: /
  5. Density: N/A
  6. Vapor Pressure: 1.28E-13mmHg at 25°C
  7. Refractive Index: N/A
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: INCADRONATE(CAS DataBase Reference)
  11. NIST Chemistry Reference: INCADRONATE(138330-18-4)
  12. EPA Substance Registry System: INCADRONATE(138330-18-4)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 138330-18-4(Hazardous Substances Data)

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138330-18-4 Suppliers

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• High quality Incadronate Disodium supplier in China

  Cas No: 138330-18-4

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• 1 Metric Ton

• 30 Metric Ton/Month

• Simagchem Corporation
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• Phosphonic acid,P,P'-[(cycloheptylamino)methylene]bis-, sodium salt (1:2)

  Cas No: 138330-18-4

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• 10000 Metric Ton/Month

• Henan Wentao Chemical Product Co., Ltd.
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• Incadronate Disodium

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• Xiamen Hisunny Chemical Co.,Ltd
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• Phosphonic acid,P,P'-[(cycloheptylamino)methylene]bis-, sodium salt (1:2)

  Cas No: 138330-18-4

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• 10 Gram

• 500 Kilogram/Month

• Zibo Hangyu Biotechnology Development Co., Ltd
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• Incadronate

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• Hunan chemfish Pharmaceutical co.,Ltd
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• Incadronate Disodium

  Cas No: 138330-18-4

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• Aecochem Corp.
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• Phosphonic acid,P,P'-[(cycloheptylamino)methylene]bis-, sodium salt (1:2)

  Cas No: 138330-18-4

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• Antimex Chemical Limied
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• Incadronate Disodium

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• Hangzhou Fandachem Co.,Ltd
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• Incadronate 138330-18-4

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• Hunan Russell Chemicals Technology Co.,Ltd
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• Incadronate 138330-18-4

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• Shenzhen Foris Technology Co. LTD
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138330-18-4 Usage

Uses

Disodium Cycloheptylaminomethylene diphosphonate inhibits squalene synthase and cholestrol biosynthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 138330-18-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,3,3 and 0 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 138330-18:
(8*1)+(7*3)+(6*8)+(5*3)+(4*3)+(3*0)+(2*1)+(1*8)=114
114 % 10 = 4
So 138330-18-4 is a valid CAS Registry Number.

InChI:InChI=1/C9H20O6P2.2Na/c10-16(11,12)9(17(13,14)15)7-8-5-3-1-2-4-6-8;;/h8-9H,1-7H2,(H2,10,11,12)(H2,13,14,15);;/q;2*+1/p-2

138330-18-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name	INCADRONATE

1.2 Other means of identification

Product number	-
Other names	cimadronate

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:138330-18-4 SDS

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138330-18-4Related news

Evaluation of long-term sequential changes in bone mass and strength following withdrawal of INCADRONATE (cas 138330-18-4) disodium (YM175) in ovariectomized rats08/25/2019

We evaluated the long-term effects of withdrawal of a newer third-generation bisphosphonate, incadronate disodium (YM175), on both cancellous and cortical bone mass and strength in ovariectomized (OVX) rats. One hundred and sixty female SD rats at 13 weeks of age were randomized into four groups...detailed

Bisphosphonate INCADRONATE (cas 138330-18-4) prevents total gastrectomy-induced osteopenia in rats08/24/2019

Purpose. Total gastrectomy (GX) leads to osteopenia. We examined the effects of bisphosphonate incadronate (INC), a potent inhibitor of bone resorption, on bone characteristics in rats that underwent total GX. Experimental design. Male Wistar rats were divided into four groups: (1) sham-operatio...detailed

Comparison of INCADRONATE (cas 138330-18-4) and alfacalcidol on increased bone turnover caused by ovariectomy in rats08/23/2019

Mineral density of trabecular bone at the metaphyses of right tibiae was measured by peripheral quantitative computed tomography (pQCT) in ovariectomized rats. Bone mineral density (BMD) decreased dramatically in the 4 weeks following ovariectomy, suggesting that the method is sensitive enough t...detailed

From Lab to ClinicLack of Prophylactic Effect of INCADRONATE (cas 138330-18-4) on Skeletal Lesions Associated with Implants of Prostate Cancer☆08/22/2019

ObjectivesTo evaluate prophylactic effects of bisphosphonate (BP) on skeletal lesions induced by prostate cancer (CaP).detailed

INCADRONATE (cas 138330-18-4) inhibits osteoporosis in ovariectomized rats08/21/2019

Incadronate is a highly effective inhibitor of stimulated bone resorption as demonstrated in a hypercalcemia model in rats, bone metastasis models in mice and rats, and an osteoporosis model in dogs. In this study, the effect of incadronate on osteoporosis in ovariectomized rats was examined. In...detailed

INCADRONATE (cas 138330-18-4) inhibits aminopeptidase N expression in prostatic PC-3 cells08/20/2019

Bone metastasis is an important cause of morbidity in advanced prostate cancer. Bisphosphonates are widely used for the treatment and prevention of osteoporosis, but recently have been observed to be effective in controlling prostate cancer metastasis. Since aminopeptidase N (AP-N) is known to b...detailed

INCADRONATE (cas 138330-18-4) disodium inhibits advanced glycation end products-induced angiogenesis in vitro☆08/19/2019

We have previously shown that advanced glycation end products (AGE), senescent macroprotein derivatives formed at an accelerated rate in diabetes, induced angiogenesis through overgeneration of autocrine vascular endothelial growth factor (VEGF). In the present study, effects of incadronate diso...detailed

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