139986-03-1

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• Basic information

  1. Product Name: (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
  2. Synonyms: (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester;(R)-tert-Butyl 3-(tosyloxy)pyrrolidine-1-carboxylate
  3. CAS NO:139986-03-1
  4. Molecular Formula: C₁₆H₂₃NO₅S
  5. Molecular Weight: 341.42252
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 139986-03-1.mol
  9. Article Data: 21

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: N/A
  3. Flash Point: N/A
  4. Appearance: /
  5. Density: N/A
  6. Refractive Index: N/A
  7. Storage Temp.: 2-8°C
  8. Solubility: N/A
  9. CAS DataBase Reference: (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
  10. NIST Chemistry Reference: (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester(139986-03-1)
  11. EPA Substance Registry System: (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester(139986-03-1)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 139986-03-1(Hazardous Substances Data)

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• Upstream product
• Downstream Products
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• (R)-tert-butyl 3-(tosyloxy)pyrrolidine-1-carboxylate

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• 4 Kilogram

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• SHANGHAI T&W PHARMACEUTICAL CO., LTD.
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• SAGECHEM/(R)-tert-Butyl 3-(tosyloxy)pyrrolidine-1-carboxylate/SAGECHEM/Manufacturer in China

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• SAGECHEM LIMITED
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• (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

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• Hunan Longxianng Runhui Trading Co.,Ltd
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• R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

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• HANGZHOU TIANYE CHEMICALS CO., LTD.
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• (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

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• ZHEJIANG JIUZHOU CHEM CO.,LTD
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• (R)-tert-Butyl 3-(tosyloxy)pyrrolidine-1-carboxylate

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• Bide Pharmatech Ltd
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• tert-Butyl 3-(R)-[(4-tolylsulfonyl)oxy]pyrrolidine-1-carboxylate

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• 10 Milligram

• Amadis Chemical Co., Ltd.
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• (R)-tert-Butyl 3-(tosyloxy)pyrrolidine-1-carboxylate

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• ENAO Chemical Co, Limited
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• (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

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• Chemical Technology Co.,LTD
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• (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester

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139986-03-1 Usage

General Description

The chemical "(R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester" is an ester compound consisting of a pyrrolidine ring with a carboxylic acid and a tert-butyl ester group. It also contains a toluene-4-sulfonyloxy group attached to the pyrrolidine ring. (R)-3-(Toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester is often used as a building block in the synthesis of pharmaceuticals and other organic compounds due to its chiral nature and the presence of functional groups that can participate in various chemical reactions. Additionally, the tert-butyl ester group provides stability and protection for the carboxylic acid functionality, making it a valuable intermediate in organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 139986-03-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,9,8 and 6 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 139986-03:
(8*1)+(7*3)+(6*9)+(5*9)+(4*8)+(3*6)+(2*0)+(1*3)=181
181 % 10 = 1
So 139986-03-1 is a valid CAS Registry Number.

139986-03-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name	tert-butyl (3R)-3-(4-methylphenyl)sulfonyloxypyrrolidine-1-carboxylate

1.2 Other means of identification

Product number	-
Other names	(3R)-1-(tert-butoxylcarbonyl)-3-p-toluenesulfonyloxypyrrolidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:139986-03-1 SDS

139986-03-1Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 

139986-03-1Downstream Products

• 143700-04-3 (R)-tert-butyl 3-azidopyrrolidine-1-carboxylate 
• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 125552-56-9 (S)-tert-butyl 3-azidopyrrolidine-1-carboxylate 
• 1233860-29-1 (S)-tert-butyl 3-(4-nitrophenoxy)pyrrolidine-1-carboxylate 
• 188616-79-7 2-[4-[(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy]phenylacetic acid ethyl ester 
• 188790-89-8 (R)-3-Diphenylphosphanyl-pyrrolidine 
• 188790-91-2 (S)-3-Diphenylphosphanyl-pyrrolidine 
• 1146960-52-2 tert-butyl 3-(2-tert-butylphenoxy)pyrrolidine-1-carboxylate 

139986-03-1Relevant articles and documents

Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use therefor for effectively treating and/or preventing FGFR-related diseases such as tumors

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Page/Page column 28-29, (2020/02/18)

The present invention relates to an alkynyl-substituted heterocyclic compound serving as an FGFR inhibitor, a preparation method therefor and a medical use therefor. In particular, the present invention relates to a compound represented by the general formula (I) and its pharmaceutically acceptable salt, a pharmaceutical composition including the compound or its pharmaceutically acceptable salt, a method for treating and/or preventing FGFR-related diseases, particularly tumors, by using the compound or its pharmaceutically acceptable salt, and a preparation method of the compound or its pharmaceutically acceptable salt. The present invention also relates to an use of the compound or its pharmaceutically acceptable salt, or an pharmaceutical composition including the compound or its pharmaceutically acceptable salt in the preparation of a drug for treating and/or preventing FGFR-related diseases, particularly tumors, wherein the definition of each substituent in the general formula (I) is the same as that in the specification.

HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF

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Paragraph 00468, (2016/05/02)

Disclosed are heteroaryl derivatives, pharmaceutical composition and uses in the manufacture of a medicine for treating respiratory diseases, especially for chronic obstructive pulmonary disease (COPD).

SUBSTITUTED N-HETEROARYL SPIROLACTAM BIPYRROLIDINES, PREPARATION AND THERAPEUTIC USE THEREOF

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Page/Page column 33, (2011/12/02)

The present invention discloses and claims a series of substituted N-heteroaryl spirolactam bipyrrolidines of formula ( Wherein R1, R2, Q1, Q2, Q3, Q4, X, m, n, p and s are as described her

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