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141575-52-2

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141575-52-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 141575-52-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,5,7 and 5 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 141575-52:
(8*1)+(7*4)+(6*1)+(5*5)+(4*7)+(3*5)+(2*5)+(1*2)=122
122 % 10 = 2
So 141575-52-2 is a valid CAS Registry Number.

141575-52-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(1-azabicyclo[2.2.2]octan-3-yl)-4-butylsulfanyl-1,2,5-thiadiazole

1.2 Other means of identification

Product number -
Other names Vedaclidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:141575-52-2 SDS

141575-52-2Downstream Products

141575-52-2Relevant articles and documents

3-(3-Alkylthio-1,2,5-thiadiazol-4-yl)-1-azabicycles. Structure-activity relationships for antinociception mediated by central muscarinic receptors

Olesen,Sauerberg,Treppendahl,Larsson,Sheardown,Suzdak,Mitch,Ward,Bymaster,Shannon,Swedberg

, p. 221 - 230 (1996)

3-(3-Alkylthio-1,2,5-thiadiazol-4-yl)-1-azabicycles (quinuclidines 7a-f; exo-1-azanorbornanes 8a-f and endo-1-azanorbornanes 9a-f) constitute a new class of muscarinic antinociceptive agents. A novel route for the synthesis of these compounds was constructed starting from the azabicyclic ketones. The compounds showed high affinity for muscarinic receptors as evidenced by inhibition of [3H]oxotremorine-M ([3H]Oxo-M) binding to brain homogenate (IC50 = 0.49-26 nM). In vivo, the compounds produced antinociception in the mouse grid shock test at doses well below those that produced salivation and tremor, with more than a 50-fold separation for some compounds. The enantiomers of 3-(3-butylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.2]octane 7d exhibited little enantioselectivity with regard to either receptor affinity or analgesic activity.

Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: Potential application for the treatment of irritable bowel syndrome

Mitch, Charles H.,Brown, Thomas J.,Bymaster, Frank P.,Calligaro, David O.,Dieckman, Donna,Merrit, Leander,Peters, Steven C.,Quimby, Steven J.,Shannon, Harlan E.,Shipley, Lisa A.,Ward, John S.,Hansen, Kristian,Olesen, Preben H.,Sauerberg, Per,Sheardown, Malcolm J.,Swedberg, Michael D. B.,Suzdak, Peter,Greenwood, Beverley

, p. 538 - 546 (2007/10/03)

Irritable bowel syndrome (IBS) is a pathophysiolocal condition characterized by abnormal bowel habits that are frequently accompanied by abdominal pain. Current therapy based on reducing high-amplitude GI contractions with nonselective muscarinic antagoni

Certain 3-(1,2,5-oxa- or thiadiazol-4-yl)-1-azabicyclo [2.2.2]octanes having pharmaceutical properties

-

, (2008/06/13)

The present invention relates to therapeutically active piperidine compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful as stimulants of the cognitive function of the forebrain and hippocampus of mammals and especially in the treatment of Alzheimer's disease, severe painful conditions and glaucoma.

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