141781-17-1Relevant articles and documents
Novel tsao derivatives modified at positions 3″ and 4″ of the spiro moiety
Lobaton,Velazquez,San-Felix,Chamorro,Tunon,Esteban-Gamboa,De Clercq,Balzarini,Camarasa,Perez-Perez
, p. 675 - 676 (1999)
We have explored the introduction of different functional groups at positions 3″ and 4″ of the spiro moiety of TS AO-T. Alkylation of this spiro moiety afforded mixtures of N and/or C-alkylated derivatives, while acylation occurs, exclusively, on the amino group. Position 3" has been selectively functionalized by halogenation followed by Stille-cross coupling reaction with organostannanes under a variety of experimental conditions. Copyright
TSAO derivatives: Highly specific inhibitors of human immunodeficiency virus type-1 (HIV-1) replication
Camarasa,Perez-Perez,Velazquez,San-Felix,Alvarez,Ingate,Jimeno,Karlsson,De Clercq,Balzarini
, p. 585 - 594 (2007/10/02)
TSAO derivatives represent a unique class of nucleosides that are specifically targeted at HIV-1 RT. This overview is focussed on the chemical synthesis, the conformational studies, the antiviral and metabolic properties of TSAO derivatives, as well as th
TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1- [2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides
Perez-Perez,San-Felix,Balzarini,De Clercq,Camarasa
, p. 2988 - 2995 (2007/10/02)
Several analogues of a new lead for anti-HIV-1 agents [1-[2',5'-bis-O- (tert-butyldimethylsilyl)-β-D-ribofuranosyl]-thymine]-3'-spiro-5''-(4''- amino-1'',2''-oxathiole 2'',2''-dioxide) (TSAO) modified at positions N-3, O- 4 and C-5 of the thymine moiety,