141894-65-7Relevant articles and documents
Synthesis of γ-hydroxybutenolides applying crossed aldol condensation in the presence of a bulky Lewis acid and their anti-tumor activity
Yamano, Yumiko,Fujita, Yumi,Mizuguchi, Yukari,Nakagawa, Kimie,Okano, Toshio,Ito, Masayoshi,Wada, Akimori
, p. 1365 - 1370 (2008/09/16)
An improved synthesis of γ-hydroxybutenolides 1a - d was achieved via crossed aldol condensation between aldehydes 2a - d and the protected γ-hydroxy-β-methylbutenolides 3 or 4 using the bulky Lewis acid, aluminum tris(2,6-diphenylphenoxide) (ATPH). Using this same methodology, the γ-hydroxybutenolides 17a - d having various heteroaromatic rings were synthesized and their anti-tumor activities were evaluated.