1420-08-2

• 

• Basic information

  1. Product Name: desacetamidocolchicine
  2. Synonyms: desacetamidocolchicine;6,7-Dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one;Deacetamidocolchicine;Deacetylaminocolchicine;Desacetylaminocolchicine
  3. CAS NO:1420-08-2
  4. Molecular Formula: C20H22O5
  5. Molecular Weight: 342.389
  6. EINECS: N/A
  7. Product Categories: N/A
  8. Mol File: 1420-08-2.mol
  9. Article Data: 2

• Chemical Properties

  1. Melting Point: N/A
  2. Boiling Point: 599.7°Cat760mmHg
  3. Flash Point: 264.1°C
  4. Appearance: /
  5. Density: 1.21g/cm³
  6. Vapor Pressure: 2.42E-14mmHg at 25°C
  7. Refractive Index: 1.581
  8. Storage Temp.: N/A
  9. Solubility: N/A
  10. CAS DataBase Reference: desacetamidocolchicine(CAS DataBase Reference)
  11. NIST Chemistry Reference: desacetamidocolchicine(1420-08-2)
  12. EPA Substance Registry System: desacetamidocolchicine(1420-08-2)

• Safety Data

  1. Hazard Codes: N/A
  2. Statements: N/A
  3. Safety Statements: N/A
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 1420-08-2(Hazardous Substances Data)

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• 1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

  Cas No: 1420-08-2

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• BOC Sciences
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• desacetamidocolchicine

  Cas No: 1420-08-2

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• Shanghai Run-Biotech Co., Ltd.
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1420-08-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1420-08-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,4,2 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1420-08:
(6*1)+(5*4)+(4*2)+(3*0)+(2*0)+(1*8)=42
42 % 10 = 2
So 1420-08-2 is a valid CAS Registry Number.

InChI:InChI=1/C20H22O5/c1-22-16-9-8-14-12(10-15(16)21)6-5-7-13-11-17(23-2)19(24-3)20(25-4)18(13)14/h8-11H,5-7H2,1-4H3

1420-08-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name	1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one

1.2 Other means of identification

Product number	-
Other names	Deacetylaminocolchicine

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1420-08-2 SDS

1420-08-2Upstream product

• 5320-47-8 Desacetamido-colchicein 
• 74-88-4 methyl iodide 
• 97860-63-4 6',7'-dihydro-13'-oxo-1',2',3'-trimethoxyspiro<1,3-dioxane-2,10'(5'H)-<7a,11>(epoxymethano)benzoheptalene> 
• 103532-92-9 C₂₀H₂₀O₆ 
• 97827-49-1 deacetamidoisocolchicide 
• 3660-48-8 deacetamidoisocolchiceinamide 
• 3476-63-9 Eschenmoser's α-pyrone 
• 186581-53-3 diazomethane 

1420-08-2Downstream Products

1420-08-2Related news

Stereochemistry of colchicinoids. Enantiomeric stability and binding to tubulin of desacetamidocolchicine (cas 1420-08-2) and desacetamidoisocolchicine09/24/2019

Desacetamidocolchicine (3) and desacetamidoisocolchicine (4) have been chromatographically resolved into enantiomers. Thermal racemization gives inversion barriers of 22.1 and 23.4 kcal mol−1, respectively, for rotation around the bond joining the two aromatic rings. Kinetic binding experiments ...detailed

1420-08-2Relevant articles and documents

Thermal, four-carbon + three-carbon cycloaddition reaction of cyclopropenone ketals. Total synthesis of deacetamidocolchiceine: Formal total synthesis of colchicine

Boger,Brotherton

, p. 3425 - 3427 (1985)

-

Discovery of structurally simplified analogs of colchicine as an immunosuppressant

Chang, Dong-Jo,Kim, Wan-Joo

, p. 3121 - 3125 (2014/06/24)

We have discovered a new class of colchicine-derived therapeutic agents for immune diseases including rejection of organ-transplantation and autoimmune disease. Compound 2, which had been developed to overcome poor pharmacokinetic properties of compound 1, a first-generation colchicine analog, turned out to show toxicity such as intestinal toxicity and loss of weight during in vivo tests. The deletion of 7-carboxamide group and middle ring-truncation in colchicine allowed us to have structurally simplified analogs with strong immunosuppressive activity. Herein, we report non-alkaloid tricyclic compound 7 and 12 as immunosuppressants which exhibited a strong immunosuppressive in vivo efficacy on the T-dependent antibody response, the Zymosan A-induced arthritis model and the Carrageenan-induced edema model. Compound 7 and 12 revealed less toxicity than the previous lead compound 2, and their minimum lethal doses (MLD) were proved to exceed 100 mg/kg.

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