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142643-29-6

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142643-29-6 Usage

Chemical Properties

White powder

Uses

Different sources of media describe the Uses of 142643-29-6 differently. You can refer to the following data:
1. Reagent for:Preparation of 9-substituted phenanthrene-based tylophorine analogsEnzymatic acylation
2. Reagent for: Preparation of Tylophorine analogs Enzymatic acylation

Check Digit Verification of cas no

The CAS Registry Mumber 142643-29-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,6,4 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 142643-29:
(8*1)+(7*4)+(6*2)+(5*6)+(4*4)+(3*3)+(2*2)+(1*9)=116
116 % 10 = 6
So 142643-29-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13-8-9-5-4-6-12-7-9/h9,12H,4-8H2,1-3H3,(H,13,14)/p+1/t9-/m0/s1

142643-29-6 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
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  • Detail
  • Alfa Aesar

  • (H60257)  (±)-3-(Boc-aminomethyl)piperidine, 98%   

  • 142643-29-6

  • 250mg

  • 485.0CNY

  • Detail
  • Alfa Aesar

  • (H60257)  (±)-3-(Boc-aminomethyl)piperidine, 98%   

  • 142643-29-6

  • 1g

  • 1621.0CNY

  • Detail
  • Aldrich

  • (55787)  (±)-3-(Boc-aminomethyl)piperidine  ≥98.0% (TLC)

  • 142643-29-6

  • 55787-500MG-F

  • 1,359.54CNY

  • Detail
  • Aldrich

  • (653896)  3-(Boc-aminomethyl)piperidine  95%

  • 142643-29-6

  • 653896-1G

  • 305.37CNY

  • Detail
  • Aldrich

  • (653896)  3-(Boc-aminomethyl)piperidine  95%

  • 142643-29-6

  • 653896-10G

  • 1,700.01CNY

  • Detail

142643-29-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(Boc-Aminomethyl)piperidine

1.2 Other means of identification

Product number -
Other names tert-Butyl (piperidin-3-ylmethyl)carbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:142643-29-6 SDS

142643-29-6Relevant articles and documents

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

Knez, Damijan,Brus, Boris,Coquelle, Nicolas,Sosi?, Izidor,?ink, Roman,Brazzolotto, Xavier,Mravljak, Janez,Colletier, Jacques-Philippe,Gobec, Stanislav

, p. 4442 - 4452 (2015)

Tremendous efforts have been dedicated to the development of effective therapeutics against Alzheimer's disease, which represents the most common debilitating neurodegenerative disease. Multifunctional agents are molecules designed to have simultaneous effects on different pathological processes. Such compounds represent an emerging strategy for the development of effective treatments against Alzheimer's disease. Here, we report on the synthesis and biological evaluation of a series of nitroxoline-based analogs that were designed by merging the scaffold of 8-hydroxyquinoline with that of a known selective butyrylcholinesterase inhibitor that has promising anti-Alzheimer properties. Most strikingly, compound 8g inhibits self-induced aggregation of the amyloid beta peptide (Aβ1-42), inhibits with sub-micromolar potency butyrylcholinesterase (IC50 = 215 nM), and also selectively complexes Cu2+. Our study thus designates this compound as a promising multifunctional agent for therapeutic treatment of Alzheimer's disease. The crystal structure of human butyrylcholinesterase in complex with compound 8g is also solved, which suggests ways to further optimize compounds featuring the 8-hydroxyquinoline scaffold.

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents

Ko?ak, Urban,Knez, Damijan,Brus, Boris,Pi?lar, Anja,Kos, Janko,Gobec, Stanislav,Coquelle, Nicolas,Colletier, Jacques-Philippe,Nachon, Florian,Brazzolotto, Xavier

, p. 633 - 645 (2016/12/30)

In the brains of patients with Alzheimer's disease, the enzymatic activities of butyrylcholinesterase (BChE) and monoamine oxidase B (MAO-B) are increased. While BChE is a viable therapeutic target for alleviation of symptoms caused by cholinergic hypofunction, MAO-B is a potential therapeutic target for prevention of neurodegeneration in Alzheimer's disease. Starting with piperidine-based selective human (h)BChE inhibitors and propargylamine-based MAO inhibitors, we have designed, synthesized and biochemically evaluated a series of N-propargylpiperidines. All of these compounds inhibited hBChE with good selectivity over the related enzyme, acetylcholinesterase, and crossed the blood-brain barrier in a parallel artificial membrane permeation assay. The crystal structure of one of the inhibitors (compound 3) in complex with hBChE revealed its binding mode. Three compounds (4, 5, 6) showed concomitant inhibition of MAO-B. Additionally, the most potent hBChE inhibitor 7 and dual BChE and MAO-B inhibitor 6 were non-cytotoxic and protected neuronal SH-SY5Y cells from toxic amyloid β-peptide species.

QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS

-

Page/Page column 279-280, (2008/06/13)

The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

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