14279-91-5 Usage
Uses
p-Chlorophenylguanidine Hydrochloride is an reagent used in the synthesis of pyrimidine derivatives as hSMG-1 inhibitors, potential targets for cancer treatment.
Biological Activity
4-chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase [1].urokinase is a serine protease. its primary physiological substrate is plasminogen, which is an inactive form of plasmin. urokinase plays an important role in vascular diseases and cancer.4-chlorophenylguanidine hydrochloride inhibited urokinase and trypsin with ki value of 6.07 μm and 120 μm, respectively [1].
references
[1]. yang h, henkin j, kim kh, et al. selective inhibition of urokinase by substituted phenylguanidines: quantitative structure-activity relationship analyses. j med chem, 1990, 33(11): 2956-2961.
Check Digit Verification of cas no
The CAS Registry Mumber 14279-91-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,2,7 and 9 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14279-91:
(7*1)+(6*4)+(5*2)+(4*7)+(3*9)+(2*9)+(1*1)=115
115 % 10 = 5
So 14279-91-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H8ClN3/c8-5-1-3-6(4-2-5)11-7(9)10/h1-4H,(H4,9,10,11)/p+1
