14283-35-3 Usage
General Description
Trimethylsilylmethylisocyanate is a chemical compound with the molecular formula C5H11NOSi. It is a colorless liquid with a boiling point of 116-117°C and a molecular weight of 125.23 g/mol. It is commonly used as a reagent in organic synthesis, particularly in the preparation of carboxamides and ureas. Trimethylsilylmethylisocyanate is highly reactive and can undergo a variety of reactions, such as addition to aldehydes and ketones to form carbamates, and addition to amines to form ureas. Its reactivity and versatility make it a valuable tool in the field of organic chemistry. However, it should be handled with caution due to its potential to cause skin and eye irritation.
Check Digit Verification of cas no
The CAS Registry Mumber 14283-35-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,2,8 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14283-35:
(7*1)+(6*4)+(5*2)+(4*8)+(3*3)+(2*3)+(1*5)=93
93 % 10 = 3
So 14283-35-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H11NOSi/c1-8(2,3)5-6-4-7/h5H2,1-3H3
14283-35-3Relevant articles and documents
Antitumour imidazotetrazines. Part 33. New synthesis of the antitumour drug temozolomide using 'masked' methyl isocyanates
Wang, Yongfeng,Stevens, Malcolm F. G.,Thomson, William T.,Shutts, Bruce P.
, p. 2783 - 2789 (2007/10/02)
Ethyl 8-carbamoyl-4-oxo-3,4-dihydroimidazo-1,2,3,5-tetrazin-3-ylacetate 6a can be prepared by treating 5-diazoimidazole-4-carboxamide 3 with ethyl isocyanatoacetate or by diazotisation of N-(5-amino-4-carbamoylimidazol-1-ylcarbonyl)glycine ethyl ester 5.Barton radical decarboxylation of the tetrazin-3-ylacetic acid 6b affords temozolomide 1 (26percent) whereas deprotection of the 3-trimethylsilylmethylimidazotetrazine 6g with TBAF in acetonitrile-acetic acid yields 1 in 78percent yield. 3-Benzylimidazotetrazinones 10a-c are stable to hydrogenolytic or oxidative debenzylation reactions.
New methods and reagents in organic synthesis. 17. Trimethylsilyldiazomethane (TMSCHN2) as a stable and safe substitute for hazardous diazomethane. Its application to the Arndt-Eistert synthesis
Aoyama,Shioiri
, p. 3249 - 3255 (2007/10/02)
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