143697-03-4 Usage
Description
(4-METHYL-2-NITRO)BENZENEBORONIC ACID, with the molecular formula C7H7BNO4, is a boronic acid derivative that plays a significant role in organic synthesis and medicinal chemistry. Its unique chemical structure, featuring a boronic acid functional group and a nitro group, endows it with distinctive reactivity and makes it a key reagent in various chemical reactions.
Uses
Used in Organic Synthesis:
(4-METHYL-2-NITRO)BENZENEBORONIC ACID is used as a key reagent in Suzuki-Miyaura cross-coupling reactions for the formation of carbon-carbon bonds. Its boronic acid functional group allows for the efficient formation of these bonds, which are crucial in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
(4-METHYL-2-NITRO)BENZENEBORONIC ACID is used as a precursor in the synthesis of pharmaceuticals and agrochemicals. Its unique reactivity and the presence of the nitro group enable the introduction of this functional group into more complex molecules, contributing to the development of novel therapeutic agents and agrochemicals.
Used in the Synthesis of Complex Molecules:
(4-METHYL-2-NITRO)BENZENEBORONIC ACID is used as a versatile building block in the synthesis of complex organic molecules. Its reactivity and the presence of the nitro group allow for the introduction of this functional group into more complex structures, facilitating the development of innovative compounds with potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 143697-03-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,6,9 and 7 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 143697-03:
(8*1)+(7*4)+(6*3)+(5*6)+(4*9)+(3*7)+(2*0)+(1*3)=144
144 % 10 = 4
So 143697-03-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H8BNO4/c1-5-2-3-6(8(10)11)7(4-5)9(12)13/h2-4,10-11H,1H3
143697-03-4Relevant articles and documents
Promoting reductive tandem reactions of nitrostyrenes with Mo(CO)6 and a palladium catalyst to produce 3 h -indoles
Jana, Navendu,Zhou, Fei,Driver, Tom G.
supporting information, p. 6738 - 6741 (2015/06/16)
The combination of Mo(CO)6 and 10 mol % of palladium acetate catalyzes the transformation of 2-nitroarenes to 3H-indoles through a tandem cyclization-[1,2] shift reaction of in situ generated nitrosoarenes. Mo(CO)6 appears to have dual roles in this transformation: generate CO and promote C-N bond formation to increase the yield of the N-heterocycle product.
A facile and convenient synthesis of functionalized ortho- nitrophenylboronic acids
Collibee, Scott E.,Yu, Jiaxin
, p. 4453 - 4455 (2007/10/03)
A variety of ortho-nitrophenylboronic acids bearing functional groups such as cyano, nitro, halo, α-bromomethyl, and ester were prepared in good yields via I-Mg exchange followed by quenching with trimethyl borate. All reagents employed in this procedure are commercially available and were used without further purification, and the procedure can be executed in about an hour.