144282-41-7Relevant articles and documents
Preparation method for efficiently synthesizing Sitafloxacin midbody (7S)-5-azaspiro[2.4] heptanes-7-phenylbutane
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, (2017/02/17)
The invention discloses a preparation method for efficiently synthesizing Sitafloxacin midbody (7S)-5-azaspiro[2.4] heptanes-7-phenylbutane. The method comprises the following steps that a first material shown as the accompanying drawing takes a reaction to obtain a second material shown as the accompanying drawing; the second material takes a reaction to obtain a third material shown as the accompanying drawing; the third material takes a reaction to obtain a fourth material shown as the accompanying drawing; the fourth material takes a reaction to obtain a fifth material shown as the accompanying drawing. The preparation method has the advantages that the single compound with a high ee value can be obtained; the unnecessary waste of materials is avoided; the yield is obviously improved; the operation is simple; the industrial application is easy; the production cost is reduced.
An efficient synthesis of a key intermediate of DU-6859a via asymmetric microbial reduction
Satoh, Koji,Imura, Akihiro,Miyadera, Akihiko,Kanai, Kazuaki,Yukimoto, Yusuke
, p. 587 - 590 (2007/10/03)
An efficient synthetic method for the C-7 substituent of DU-6859a (1), which is a new-generation antibacterial quinolone carboxylic acid, was established by utilizing an enantioselective microbial reduction of 5- benzyl-4,7-dioxo-5-azaspiro[2,4]heptane (7) to the corresponding chiral alcohol (8) as the key reaction. This synthetic method was based on use of AIPHOS (Artificial Intelligence for Planning and Handling Organic Synthesis), which is a synthesis design system that generates suitable retrosynthetic routes from the standpoints of both novelty and practicality.
