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144409-99-4

144409-99-4

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  • L-Aspartic acid,L-valyl-L-valylglycylglycyl-L-valyl-L-methionyl-L-leucylglycyl-L-isoleucyl-L-isoleucyl-L-alanylglycyl-L-lysyl-L-asparaginyl-L-serylglycyl-L-valyl-L-a-aspartyl-L-a-glutamyl-L-alanyl-L-p

    Cas No: 144409-99-4

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144409-99-4 Usage

Description

Amyloid beta-protein (40-1), also known as Aβ40-1, is a peptide fragment derived from the larger amyloid precursor protein (APP) through proteolytic cleavage. It is a significant component of amyloid plaques, which are a pathological hallmark of Alzheimer's disease. Aβ40-1 has the potential to form toxic aggregates that can disrupt neuronal function and contribute to neuronal damage and death. The peptide's aggregation and toxicity are central to the pathogenesis of Alzheimer's disease, and understanding these mechanisms is essential for developing potential therapeutic interventions.

Uses

Used in Pharmaceutical Research and Development:
Amyloid beta-protein (40-1) is used as a target for developing drugs and therapies aimed at preventing or reducing its aggregation and toxicity in Alzheimer's disease. This includes the development of small molecules, antibodies, and other agents that can modulate Aβ40-1 aggregation, clearance, or interaction with neurons.
Used in Diagnostic Applications:
Aβ40-1 can be used as a biomarker for the early diagnosis and monitoring of Alzheimer's disease. Detecting the presence and levels of Aβ40-1 in biological samples, such as cerebrospinal fluid or blood, can help in identifying individuals at risk or in the early stages of the disease.
Used in Neurodegenerative Disease Research:
Amyloid beta-protein (40-1) is used as a model system to study the molecular mechanisms underlying neurodegeneration in Alzheimer's disease and other related disorders. Investigating the structure, aggregation, and toxicity of Aβ40-1 can provide insights into the pathophysiology of these diseases and identify potential therapeutic targets.
Used in Drug Screening and Toxicity Testing:
Aβ40-1 can be employed in high-throughput screening assays to identify compounds with potential neuroprotective or anti-aggregation properties. Additionally, it can be used in toxicity testing to evaluate the safety and efficacy of newly developed drugs and therapies targeting Alzheimer's disease.
Used in Biomarker Development for Alzheimer's Disease:
Amyloid beta-protein (40-1) can be utilized in the development of diagnostic tools and tests that measure its levels in biological samples. These biomarkers can aid in the early detection, prognosis, and monitoring of Alzheimer's disease progression, enabling more timely and effective treatment interventions.

Check Digit Verification of cas no

The CAS Registry Mumber 144409-99-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,4,0 and 9 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 144409-99:
(8*1)+(7*4)+(6*4)+(5*4)+(4*0)+(3*9)+(2*9)+(1*9)=134
134 % 10 = 4
So 144409-99-4 is a valid CAS Registry Number.

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