144689-24-7 Usage
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 144689-24-7 differently. You can refer to the following data:
1. An labelled angiotensin II receptor antagonist. Used as an anti-hypertensive
2. An angiotensin II receptor antagonist. Used as an anti-hypertensive
3. Angiotensin II inhibitor, antihypertensive
4. An angiotensin II (AT1) receptor antagonist
5. Olmesartan Acid (Olmesartan EP Impurity A) is an angiotensin II receptor antagonist. Used as an anti-hypertensive.
General Description
Olmesartan medoxomil, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl-5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate (Benicar, Olmetec) uses the tetrazolering system as its acidic system, which participates inreceptor binding.When administered to a patient, the drugis rapidly and completely bioactivated by ester hydrolysis ofthe medoxomil during absorption from the gastrointestinaltract. Once the prodrug is converted to the active form, virtuallyno further metabolism occurs. In September 2007, theFood and Drug Administration (FDA) approved its use as acombination product with the calcium channel blocker amlodipinefor the management of hypertension. This combinationproduct is sold under the tradename of Azor.
Biochem/physiol Actions
Olmesartan possesses anti-inflammatory and anti-oxidative stress properties. It protects neuronal cells against oligomerized amyloid β (Aβ)-induced cellular senescence.
Check Digit Verification of cas no
The CAS Registry Mumber 144689-24-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,6,8 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 144689-24:
(8*1)+(7*4)+(6*4)+(5*6)+(4*8)+(3*9)+(2*2)+(1*4)=157
157 % 10 = 7
So 144689-24-7 is a valid CAS Registry Number.
