1461-94-5Relevant articles and documents
Novel synthesis method of lobaplatin intermediate
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, (2021/09/22)
The invention relates to the technical field of drug synthesis, in particular to a novel synthesis method of a loxetine intermediate, which is coupled through low-toxicity dimethyl malonate as a starting raw material. The synthesis of high purity trans -1, 2 - dicyanocyclobutane is carried out after the reaction of bromination, cyclization, hydrolysis, amidation and dehydration. In addition, the yield of the product is greatly improved, so that the cost is greatly reduced, the obtained trans -1 and 2 -dicyanocyclobutane are improved in purity, the subsequent use requirements are completely met, and the market competitiveness is greatly improved.
The synthesis and use in asymmetric epoxidation of metal salen complexes derived from enantiopure trans-cyclopentane- and cyclobutane-1,2-diamine
Daly, Adrian M.,Gilheany, Declan G.
, p. 127 - 137 (2007/10/03)
A complete synthesis of enantiopure trans-cyclopentane-1,2-diamine and trans-cyclobutane-1,2-diamine is described. These diamines have been used as components of novel chiral salen ligands whose chromium and manganese complexes were then evaluated as oxygen transfer agents in the asymmetric epoxidation of alkenes.
Preparation of Small Ring Carbocycles via Intramolecular Oxidative Coupling of Bisenolates Derived from α,ω-Diesters
Babler, James H.,Sarussi, Steven J.
, p. 3462 - 3464 (2007/10/02)
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